{"id":"W4225131018","doi":"10.1016/j.ymeth.2022.04.013","title":"Mapping of sister chromatid exchange events and genome alterations in single cells","year":2022,"lang":"en","type":"article","venue":"Methods","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Genome British Columbia; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Canada Foundation for Innovation","keywords":"Helicase; Biology; Genetics; Sister chromatids; Genome; Sister chromatid exchange; Genome instability; DNA; DNA replication; DNA repair; Homologous recombination; Computational biology; DNA damage; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000357913,0.0002874901,0.0003166732,0.0007266346,0.0003531202,0.0004919565,0.0004727575,0.0004334571,0.002370514],"category_scores_gemma":[0.0003483553,0.0004003366,0.0002850911,0.0005238688,0.0003495617,0.0002760263,0.0003907357,0.0007458043,0.0007113863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105081,"about_ca_system_score_gemma":0.0002184121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007980307,"about_ca_topic_score_gemma":0.001770739,"domain_scores_codex":[0.9997441,0.00004030534,0.00003192845,0.0000801128,0.00007149851,0.00003195422],"domain_scores_gemma":[0.9995266,0.0001905587,0.00006343181,0.0001266558,0.00002996941,0.00006271996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004094827,0.00001606529,0.000266222,0.00002586514,0.000003579539,0.00002448666,0.00001806419,0.00005286124,0.997833,0.0001536113,0.00001538036,0.001549975],"study_design_scores_gemma":[0.000007098786,0.00006725718,0.006774568,0.000003916955,0.000009397479,0.0002458679,0.00003299648,0.0007178287,0.9907177,0.0001084916,0.001310757,0.000004171311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9068075,0.001905438,0.08574755,0.0001277293,0.00007704934,0.0001899953,0.001460131,0.0005034008,0.003181139],"genre_scores_gemma":[0.9247062,0.001530828,0.06172707,0.00008786541,0.00002043724,0.0003282198,0.001690175,0.0002067625,0.00970251],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002370514,"threshold_uncertainty_score":0.00793016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03127255136452635,"score_gpt":0.3095153368714325,"score_spread":0.2782427855069061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}