{"id":"W4225134613","doi":"10.1371/journal.ppat.1010504","title":"The SUMO E3 ligase activity of ORF45 determines KSHV lytic replication","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Dental and Craniofacial Research; School of Medicine, Shanghai Jiao Tong University; National Institutes of Health; Shanghai Jiao Tong University; Science and Technology Commission of Shanghai Municipality; Shanghai Municipal Health Commission; Innovative Research Team of High-level Local University in Shanghai","keywords":"Lytic cycle; SUMO protein; Biology; Ubiquitin ligase; Viral replication; Kaposi's sarcoma-associated herpesvirus; Cell biology; Molecular biology; DNA ligase; Virology; Gene; Virus; Ubiquitin; Genetics; Herpesviridae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163065,0.000194437,0.0001663922,0.0002023664,0.0001404184,0.0003892712,0.00008968823,0.0001585769,0.0007321848],"category_scores_gemma":[0.0001569666,0.0001284637,0.0002513571,0.0001241487,0.0001756881,0.0002068482,0.0002278047,0.0001708384,0.0003177232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003019192,"about_ca_system_score_gemma":0.0001399954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004767998,"about_ca_topic_score_gemma":0.0005147986,"domain_scores_codex":[0.999872,0.00001867759,0.00001004078,0.00003793008,0.00002584856,0.00003556174],"domain_scores_gemma":[0.9998952,0.0000174217,0.00003280836,0.00001154973,0.00001208815,0.00003098044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004791596,0.000005468222,0.001091541,0.00001101996,0.000002231898,0.00002937876,0.00001341752,0.00003396846,0.9978291,0.00008369365,0.00001127724,0.0008408546],"study_design_scores_gemma":[0.000004027226,0.00009735892,0.02991029,0.000003795385,0.0000132095,0.0002855739,0.00004384805,0.001051537,0.9667161,0.00007009504,0.001799254,0.000004841833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973577,0.0005322368,0.001356643,0.00001758848,0.000006328689,0.000005096032,0.0001336256,0.00003196251,0.0005589522],"genre_scores_gemma":[0.9987662,0.0001416021,0.0003975828,0.000007809939,0.000001893695,0.000001940432,0.0001805335,0.000006706366,0.0004956097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007321848,"threshold_uncertainty_score":0.002449393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458312052995614,"score_gpt":0.2713817075094433,"score_spread":0.2467985869794872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}