{"id":"W4225134613","doi":"10.1371/journal.ppat.1010504","title":"The SUMO E3 ligase activity of ORF45 determines KSHV lytic replication","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Dental and Craniofacial Research; School of Medicine, Shanghai Jiao Tong University; National Institutes of Health; Shanghai Jiao Tong University; Science and Technology Commission of Shanghai Municipality; Shanghai Municipal Health Commission; Innovative Research Team of High-level Local University in Shanghai","keywords":"Lytic cycle; SUMO protein; Biology; Ubiquitin ligase; Viral replication; Kaposi's sarcoma-associated herpesvirus; Cell biology; Molecular biology; DNA ligase; Virology; Gene; Virus; Ubiquitin; Genetics; Herpesviridae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002419924,0.00008893583,0.0001853924,0.00004041777,0.0002715721,0.000007698505,0.0001073868,0.00003235825,0.0000749976],"category_scores_gemma":[0.0003196211,0.00006850233,0.0001066517,0.0002380236,0.00004896745,0.00003061653,0.00007151,0.0001444473,0.000007090994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001364029,"about_ca_system_score_gemma":0.000128343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005489989,"about_ca_topic_score_gemma":0.00002602852,"domain_scores_codex":[0.9990458,0.00007028187,0.0001711063,0.0002229322,0.0003032516,0.0001866111],"domain_scores_gemma":[0.9990597,0.00009102582,0.0001635223,0.0005561365,0.00007171091,0.00005791342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005778727,0.0007374162,0.03698175,0.0001003195,0.0001748604,0.00003880106,0.0007883619,0.00003745258,0.913573,0.0001478349,0.00398572,0.04285664],"study_design_scores_gemma":[0.009669218,0.004013897,0.2437686,0.0001762154,0.001984069,0.0001153784,0.005006155,0.01285809,0.6797365,0.002122636,0.03951281,0.001036461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995408,0.0003507114,0.000007004742,0.001769846,0.00006825337,0.0003301192,0.0000697724,0.00004459365,0.001951726],"genre_scores_gemma":[0.9983302,0.0001367487,0.00002468066,0.0002843911,0.00004997517,0.0001333667,0.00002009274,0.00001879027,0.001001715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2338365,"threshold_uncertainty_score":0.2793444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458312052995614,"score_gpt":0.2713817075094433,"score_spread":0.2467985869794872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}