{"id":"W4225136238","doi":"10.1042/bst20211203","title":"Transgenic mouse models to study the physiological and pathophysiological roles of human Siglecs","year":2022,"lang":"en","type":"article","venue":"Biochemical Society Transactions","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Genetically modified mouse; Transgene; Immune system; In vivo; Sialic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001166852,0.001199409,0.0008077571,0.001706272,0.0003921554,0.0009315357,0.0009450642,0.001589876,0.005677938],"category_scores_gemma":[0.0004564416,0.0004270363,0.0007423168,0.0006646937,0.0005819272,0.0007808342,0.0005553227,0.002784589,0.001810407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006406146,"about_ca_system_score_gemma":0.0005389259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004620736,"about_ca_topic_score_gemma":0.0008202029,"domain_scores_codex":[0.9993325,0.0001628155,0.00008456106,0.0001198572,0.0002084973,0.00009169899],"domain_scores_gemma":[0.999517,0.0001213128,0.0001366463,0.00006166459,0.00007567166,0.00008768519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005523812,0.0005365422,0.0008078896,0.001029163,0.0001217268,0.0006600667,0.0001218294,0.000548386,0.9563185,0.008123359,0.005406534,0.02577368],"study_design_scores_gemma":[0.0006300359,0.00422093,0.005728241,0.0008561639,0.0008509361,0.00709679,0.0002436607,0.003652862,0.6891446,0.00541213,0.2820483,0.0001153341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5094617,0.121855,0.2860508,0.006928489,0.003645543,0.00283517,0.02003602,0.006641531,0.04254568],"genre_scores_gemma":[0.5535844,0.1688116,0.1763814,0.004256728,0.0007867509,0.00687084,0.02721245,0.000972086,0.06112368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005677938,"threshold_uncertainty_score":0.01899457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0427821269776215,"score_gpt":0.2943580224918713,"score_spread":0.2515758955142498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}