{"id":"W4225136238","doi":"10.1042/bst20211203","title":"Transgenic mouse models to study the physiological and pathophysiological roles of human Siglecs","year":2022,"lang":"en","type":"article","venue":"Biochemical Society Transactions","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Genetically modified mouse; Transgene; Immune system; In vivo; Sialic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872929,0.0001253216,0.0001450498,0.00001286956,0.0005099458,0.00001094787,0.0002499325,0.0000872812,0.0001214814],"category_scores_gemma":[0.000007226573,0.00009147728,0.000220366,0.0001800547,0.0001555603,0.000002963178,0.00007904797,0.000254099,7.843003e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001491588,"about_ca_system_score_gemma":0.00002375306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002139041,"about_ca_topic_score_gemma":0.000005345863,"domain_scores_codex":[0.9988683,0.0001478437,0.0001918904,0.0003494084,0.0002394163,0.0002031807],"domain_scores_gemma":[0.9995518,0.00001810436,0.00002998628,0.000255756,0.00004857706,0.00009573078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007615794,0.0005968297,0.00001451708,0.000004737179,0.00007482807,1.613326e-7,0.0006190034,0.001273119,0.9964696,0.00002221431,0.0003667558,0.0004821112],"study_design_scores_gemma":[0.00119158,0.002548943,0.001375745,0.000001790101,0.00005089726,0.000003721307,0.00567947,0.000921487,0.9866014,0.0003586941,0.0009802373,0.000286081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926908,0.0001454288,0.006179827,0.0003162072,0.00001224852,0.0005391506,0.00007983427,0.00001572207,0.00002080559],"genre_scores_gemma":[0.9988618,0.00005342434,0.000311701,0.0002374096,0.00003303618,0.0003027052,0.00004263774,0.0000116796,0.0001456366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009868211,"threshold_uncertainty_score":0.3922142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0427821269776215,"score_gpt":0.2943580224918713,"score_spread":0.2515758955142498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}