{"id":"W4225157426","doi":"","title":"Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma","year":2022,"lang":"en","type":"article","venue":"The Medicine Forum","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bayer (Canada)","funders":"","keywords":"Trk receptor; Medicine; Internal medicine; Adverse effect; Clinical endpoint; Response Evaluation Criteria in Solid Tumors; Oncology; Thyroid carcinoma; Progression-free survival; Phases of clinical research; Thyroid; Clinical trial; Gastroenterology; Surgery; Overall survival; Receptor; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00237387,0.0002991908,0.001070003,0.0004077896,0.0002217155,0.0006134962,0.0001876064,0.000398304,0.001909262],"category_scores_gemma":[0.001874951,0.0001328799,0.001104404,0.000488626,0.0002198259,0.0003668519,0.0002678579,0.0005936762,0.0004346873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008171966,"about_ca_system_score_gemma":0.0008013517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005568104,"about_ca_topic_score_gemma":0.00149134,"domain_scores_codex":[0.9992204,0.0003323611,0.0001126075,0.00008444729,0.0001711517,0.00007905982],"domain_scores_gemma":[0.999121,0.0003136595,0.00027844,0.0000360627,0.0001312792,0.0001195264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2134734,0.002882068,0.2138041,0.002548236,0.006901054,0.0007235322,0.0002849185,0.003148548,0.0307869,0.0002457711,0.01015942,0.5150421],"study_design_scores_gemma":[0.09179259,0.1918338,0.6411939,0.0006164092,0.01239738,0.004817271,0.0003540767,0.007180184,0.0133766,0.0006031157,0.03571099,0.000123716],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974143,0.01843346,0.0004679892,0.0004564834,0.00009142048,0.000343311,0.001506578,0.0000689928,0.004488792],"genre_scores_gemma":[0.9945534,0.002518665,0.0003089985,0.0004074853,0.0001304056,0.0001869403,0.001359217,0.00001110609,0.0005236758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00237387,"threshold_uncertainty_score":0.01255441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006270946548797329,"score_gpt":0.2298527079236559,"score_spread":0.2235817613748585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}