{"id":"W4225245843","doi":"10.1002/advs.202104640","title":"Nurr1 Modulation Mediates Neuroprotective Effects of Statins","year":2022,"lang":"en","type":"article","venue":"Advanced Science","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Aventis Foundation; European Commission; European Federation of Pharmaceutical Industries and Associations; McGill University; Diamond Light Source; Innovative Medicines Initiative","keywords":"Simvastatin; Neuroprotection; Gene knockdown; Pharmacology; Proinflammatory cytokine; Inflammation; Chemistry; Cell biology; Biology; Apoptosis; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002273345,0.0002986105,0.0005941896,0.0002360791,0.0002281642,0.0002893291,0.0002202797,0.0002814737,0.001640392],"category_scores_gemma":[0.0002775402,0.0001209074,0.0003901342,0.0001636781,0.0002705395,0.0002495385,0.0002913681,0.0004123046,0.0005595936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002837548,"about_ca_system_score_gemma":0.0003731539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006777227,"about_ca_topic_score_gemma":0.001573402,"domain_scores_codex":[0.9997012,0.00007010296,0.00004045827,0.00005555171,0.00005329705,0.00007944569],"domain_scores_gemma":[0.9998989,0.00001291622,0.00002749284,0.00001750076,0.00002396091,0.00001913541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007426527,0.00003205825,0.0003194973,0.0001964907,0.0000254087,0.00008741453,0.00003387146,0.00005753483,0.994699,0.0002039761,0.0001356388,0.003466517],"study_design_scores_gemma":[0.00003095881,0.0004215215,0.003593015,0.00001849386,0.00005441472,0.0002257203,0.00005312426,0.0002722849,0.9910941,0.0001308716,0.004098731,0.000006818152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689753,0.02128725,0.004182688,0.0004388131,0.00009373447,0.00006226259,0.0008106373,0.0001828077,0.00396668],"genre_scores_gemma":[0.9888496,0.006766413,0.001635793,0.0001285827,0.00003811925,0.00006125278,0.000643815,0.00002072788,0.001855831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001640392,"threshold_uncertainty_score":0.005487621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001403116766029,"score_gpt":0.2536651686401999,"score_spread":0.2436511374725396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}