{"id":"W4225245843","doi":"10.1002/advs.202104640","title":"Nurr1 Modulation Mediates Neuroprotective Effects of Statins","year":2022,"lang":"en","type":"article","venue":"Advanced Science","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Aventis Foundation; European Commission; European Federation of Pharmaceutical Industries and Associations; McGill University; Diamond Light Source; Innovative Medicines Initiative","keywords":"Simvastatin; Neuroprotection; Gene knockdown; Pharmacology; Proinflammatory cytokine; Inflammation; Chemistry; Cell biology; Biology; Apoptosis; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002460891,0.00007230858,0.00009596418,0.0001265461,0.000587785,0.00001904101,0.0003870971,0.000007058754,0.00006864759],"category_scores_gemma":[0.001147385,0.00006943013,0.00002692328,0.001121008,0.0003257695,0.0003793495,0.0001905721,0.0001440215,0.000007567955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006150432,"about_ca_system_score_gemma":0.00005770797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008386054,"about_ca_topic_score_gemma":3.455972e-7,"domain_scores_codex":[0.9985262,0.0001001627,0.0001347479,0.0003740104,0.0006383045,0.0002265539],"domain_scores_gemma":[0.9993239,0.0002747107,0.0001265231,0.0001751693,0.00004175815,0.00005793871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001288619,0.0000311179,0.00005136565,0.000007397543,2.22125e-7,0.000003705845,0.0005895204,0.01349889,0.9688852,0.00192847,0.000002496477,0.01498871],"study_design_scores_gemma":[0.0002043367,0.0002620659,0.001531336,0.000006514331,0.000001349757,0.000003844986,0.000118078,0.01431975,0.9804642,0.002684312,0.0003178835,0.00008635569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969522,0.00001681384,0.001535986,0.00004408297,0.0005279061,0.000272171,0.000005545102,0.00004780149,0.0005974286],"genre_scores_gemma":[0.9988657,0.000005927477,0.0008748606,0.0001483222,0.00001134272,0.00002974091,2.546489e-7,0.000009857142,0.00005399417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01490235,"threshold_uncertainty_score":0.4520826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001403116766029,"score_gpt":0.2536651686401999,"score_spread":0.2436511374725396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}