{"id":"W4225246326","doi":"10.1002/alz.12686","title":"Genetic variants in the <i>SHISA6</i> gene are associated with delayed cognitive impairment in two family datasets","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Human-Animal Interaction Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Leonard M. Miller School of Medicine; National Institutes of Health; Case Western Reserve University; Michael J. Fox Foundation for Parkinson's Research; University of Miami; U.S. Department of Veterans Affairs; U.S. Department of Defense","keywords":"Hazard ratio; Disease; Allele; Single-nucleotide polymorphism; Genetic association; Gene; Genetics; Chromosome; Biology; Genome-wide association study; Cognitive impairment; Cognition; Proportional hazards model; Medicine; Internal medicine; Genotype; Neuroscience; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001179194,0.0005343397,0.0005677582,0.0009118745,0.0009276245,0.0006044852,0.000562869,0.0004537014,0.005742749],"category_scores_gemma":[0.003411578,0.0001948525,0.0009714053,0.001639816,0.0003040092,0.0001840957,0.0007505839,0.0004589829,0.0003549256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002494836,"about_ca_system_score_gemma":0.0004073121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01018125,"about_ca_topic_score_gemma":0.01270281,"domain_scores_codex":[0.9992244,0.0002168593,0.0000803952,0.0002965614,0.0001020091,0.00007982891],"domain_scores_gemma":[0.9979709,0.0006579079,0.0007552857,0.0003099807,0.0001194156,0.0001864713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002008051,0.0000642253,0.9846064,0.0001067923,0.001907235,0.0008565072,0.0001995817,0.0005324132,0.003172099,0.0001494425,0.00197785,0.004419423],"study_design_scores_gemma":[0.0001420477,0.0001231473,0.9937813,0.00003653811,0.001012974,0.001484597,0.0001190247,0.0008032522,0.000685773,0.0002929866,0.001501506,0.00001692911],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923216,0.0002800003,0.0003606091,0.00009315313,0.000009915074,0.000007793883,0.00643438,0.00001954075,0.0004729017],"genre_scores_gemma":[0.9910244,0.0001460595,0.000439018,0.00004492919,0.00001247744,0.00002329285,0.007924506,0.00001019555,0.0003750384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01018125,"threshold_uncertainty_score":0.020244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02444025426394648,"score_gpt":0.3155066623982868,"score_spread":0.2910664081343404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}