{"id":"W4225246326","doi":"10.1002/alz.12686","title":"Genetic variants in the <i>SHISA6</i> gene are associated with delayed cognitive impairment in two family datasets","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Human-Animal Interaction Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Leonard M. Miller School of Medicine; National Institutes of Health; Case Western Reserve University; Michael J. Fox Foundation for Parkinson's Research; University of Miami; U.S. Department of Veterans Affairs; U.S. Department of Defense","keywords":"Hazard ratio; Disease; Allele; Single-nucleotide polymorphism; Genetic association; Gene; Genetics; Chromosome; Biology; Genome-wide association study; Cognitive impairment; Cognition; Proportional hazards model; Medicine; Internal medicine; Genotype; Neuroscience; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003378856,0.0001837991,0.0001619953,0.000063113,0.0001816555,0.00002996639,0.0002708667,0.00002934274,0.00009089934],"category_scores_gemma":[0.0000232272,0.0001541356,0.00004365214,0.0002052657,0.00005522534,0.000007673155,0.0003144703,0.0001950646,0.00001295265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001529978,"about_ca_system_score_gemma":0.00004796662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003104717,"about_ca_topic_score_gemma":0.003141358,"domain_scores_codex":[0.9983985,0.0003495693,0.0002767059,0.0004030975,0.0002626572,0.0003094498],"domain_scores_gemma":[0.999467,0.00003928791,0.0001616215,0.0002508052,0.000049848,0.00003145376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004276998,0.006753377,0.4523097,0.00001135304,0.06194144,0.001952883,0.006084845,0.002533966,0.3318728,0.00005275042,0.1280137,0.004196199],"study_design_scores_gemma":[0.005390299,0.001451657,0.9556822,0.00003065739,0.004043583,0.00006972919,0.006280387,0.0001622177,0.01648385,0.00002759157,0.009691698,0.0006861117],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833349,0.01505487,0.00003652336,0.0001120441,0.00009987956,0.0004606638,0.0006009781,0.000008421704,0.0002917352],"genre_scores_gemma":[0.9964398,0.00006032679,0.00008223372,0.0019515,0.0000396202,0.000331754,0.001066593,0.0000225073,0.000005626284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5033725,"threshold_uncertainty_score":0.6285467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02444025426394648,"score_gpt":0.3155066623982868,"score_spread":0.2910664081343404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}