{"id":"W4225248532","doi":"10.1161/circulationaha.121.057888","title":"Genetic Landscape of the ACE2 Coronavirus Receptor","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; Sun Yat-sen University; Research Councils UK; Stiftelsen för Strategisk Forskning; University of Bristol; Eesti Teadusagentuur; British Heart Foundation; Wellcome Trust; European Commission; McMaster University; National Heart, Lung, and Blood Institute; Science for Life Laboratory; Vetenskapsrådet; Pfizer; Bristol-Myers Squibb; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Coronavirus; Receptor; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Peptidyl-Dipeptidase A; 2019-20 coronavirus outbreak; Virus; Coronavirus Infections","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000230825,0.00003855798,0.000104725,0.00002931565,0.0001192314,0.000002105489,0.0000766419,0.00001683097,0.0009242619],"category_scores_gemma":[0.002506248,0.00002799632,0.00007181601,0.000214267,0.00005056255,0.00001135497,0.0001542676,0.0001371892,0.00001496664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000870888,"about_ca_system_score_gemma":0.0001122861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002946124,"about_ca_topic_score_gemma":0.000002122265,"domain_scores_codex":[0.999164,0.00008003052,0.0001541561,0.0001126224,0.000400016,0.00008917477],"domain_scores_gemma":[0.9991403,0.0004772112,0.00006024139,0.0002302468,0.00006095496,0.00003104497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006406983,0.00007074627,0.9698654,0.00006710806,0.00002999239,0.000001242986,0.0002344458,0.002612523,0.015194,0.00008554447,0.0007851863,0.01098978],"study_design_scores_gemma":[0.0004634999,0.00005578667,0.9810226,0.00001009522,0.00002359461,6.978983e-7,0.00005591484,0.002354678,0.0001339772,0.0001427135,0.01570875,0.00002770838],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964067,0.000205414,0.0001113388,0.002338896,0.0001507785,0.0003057316,0.000009670854,0.00001485061,0.0004565857],"genre_scores_gemma":[0.9992188,0.00002552916,0.00004355201,0.000382817,0.00006469633,0.00003263306,0.00000642946,0.0000063122,0.0002192068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01506002,"threshold_uncertainty_score":0.999989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07279380754506795,"score_gpt":0.3969432931374217,"score_spread":0.3241494855923537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}