{"id":"W4225249143","doi":"10.7554/elife.75374","title":"Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Medical Research Council; University of Bristol; Department of Health and Social Care; Wellcome; Canadian Institutes of Health Research; National Institute for Health and Care Research; Ovarian Cancer Research Fund; National Institutes of Health; Cancer Research UK; Alzheimer's Society; Wellcome Trust; Breast Cancer Research Foundation","keywords":"Mendelian randomization; Epidemiology; Medical research; Cancer; Research council; Cancer prevention; Genetic epidemiology; Alternative medicine; MEDLINE","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0670858,0.001831563,0.003897334,0.001506381,0.0008566252,0.001384219,0.002148495,0.002453679,0.004305337],"category_scores_gemma":[0.1291624,0.001125417,0.01070992,0.002023589,0.001406037,0.001297536,0.001109852,0.001903189,0.0004116616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008519263,"about_ca_system_score_gemma":0.00129506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002468369,"about_ca_topic_score_gemma":0.001893008,"domain_scores_codex":[0.9098954,0.0715147,0.004387891,0.01070294,0.002510093,0.0009890175],"domain_scores_gemma":[0.9166555,0.05675022,0.009571063,0.01465077,0.001777977,0.0005944254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"observational","study_design_scores_codex":[0.1113858,0.0007956332,0.3615231,0.01075817,0.4007789,0.002660604,0.001080884,0.01163002,0.00694346,0.02247292,0.006604734,0.06336583],"study_design_scores_gemma":[0.05872193,0.01803985,0.1679847,0.00220229,0.5630339,0.005057207,0.0003850424,0.09749682,0.006005852,0.06146442,0.01905037,0.0005575471],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6402842,0.03923225,0.3009455,0.002475108,0.001631074,0.006397335,0.004349978,0.001112824,0.003571857],"genre_scores_gemma":[0.9484248,0.00115602,0.04474249,0.0006710048,0.0001776261,0.003326829,0.0007491928,0.00008249546,0.0006695864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0670858,"threshold_uncertainty_score":0.3547878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02142540324544395,"score_gpt":0.3078726570249546,"score_spread":0.2864472537795107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}