{"id":"W4225253156","doi":"10.1038/s41467-022-29893-2","title":"Structure of ATP synthase under strain during catalysis","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Canada Research Chairs; Government of Canada","keywords":"ATP synthase; ATP hydrolysis; Stalk; Strain (injury); F-ATPase; Rotor (electric); Chemiosmosis; Biophysics; ATP synthase gamma subunit; ATPase; Proton; Catalysis; Bending; Chemistry; Biology; Biochemistry; Physics; Enzyme; Anatomy; Gene; Thermodynamics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008982889,0.00008545128,0.0001020917,0.00006831653,0.0003995033,0.000008857752,0.0009794972,0.0001214787,0.0001810799],"category_scores_gemma":[0.00008155613,0.00008816077,0.00009259652,0.0002460553,0.0001193576,0.000003082819,0.001085682,0.0005750649,0.000001288518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002658307,"about_ca_system_score_gemma":0.00009196352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002408924,"about_ca_topic_score_gemma":0.0001666084,"domain_scores_codex":[0.9991835,0.0001497696,0.0001497653,0.0001761071,0.0001961935,0.000144617],"domain_scores_gemma":[0.9981963,0.00003772922,0.00007345415,0.001566211,0.00007819458,0.00004809364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002461664,0.0001006832,0.0007138239,0.000008654063,0.00008430936,9.569167e-7,0.00006363865,0.0003134469,0.9971136,0.0006905813,0.0005147972,0.0003708964],"study_design_scores_gemma":[0.0007879557,0.0001712524,0.01178336,0.00001130371,0.00008105429,0.00002749929,0.002028996,0.0002130517,0.8948348,0.000239072,0.08944279,0.000378928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921694,0.005007466,0.00004621892,0.001247574,0.00003547528,0.0001237189,0.0008722495,0.00001038056,0.0004874963],"genre_scores_gemma":[0.997168,0.0002024072,0.0006827043,0.000143063,0.00003603916,0.00002187963,0.001451509,0.00001638208,0.000278013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1022789,"threshold_uncertainty_score":0.3595092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01580679236223583,"score_gpt":0.3223174091827281,"score_spread":0.3065106168204922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}