{"id":"W4225262145","doi":"10.1038/s41416-022-01823-5","title":"BRCA mutations lead to XIAP overexpression and sensitise ovarian cancer to inhibitor of apoptosis (IAP) family inhibitors","year":2022,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of Texas MD Anderson Cancer Center; Genentech; Conquer Cancer Foundation; Science Foundation Ireland; Irish Research eLibrary; Michael Smith Health Research BC; American Society of Clinical Oncology","keywords":"XIAP; Inhibitor of apoptosis; PARP inhibitor; Cancer research; Ovarian cancer; Apoptosis; Cell culture; Olaparib; Biology; In vivo; Poly ADP ribose polymerase; Cancer; Programmed cell death; Caspase; Enzyme; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001432637,0.0001850393,0.0002087101,0.0002069185,0.0001001834,0.0001771871,0.0001244613,0.0002666095,0.002277992],"category_scores_gemma":[0.0002137905,0.0001152033,0.0001590899,0.0001605973,0.0001691201,0.0001090176,0.000124467,0.0003062988,0.0002245146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002256458,"about_ca_system_score_gemma":0.0001134219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003840073,"about_ca_topic_score_gemma":0.0004079049,"domain_scores_codex":[0.9999204,0.0000168146,0.000008812906,0.00001484051,0.00002004002,0.0000191112],"domain_scores_gemma":[0.9998611,0.00004701581,0.00004257854,0.00001797658,0.000007157684,0.00002412111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000651019,0.0001614079,0.004189221,0.00005823483,0.00002573697,0.0005835035,0.00003333624,0.0003058734,0.9903095,0.0001618707,0.0001835999,0.003336657],"study_design_scores_gemma":[0.0001322165,0.00245744,0.05651206,0.00001096932,0.00004966222,0.006168662,0.00005503968,0.001461936,0.9283029,0.0001619671,0.004679067,0.000008032132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983259,0.0005956538,0.0002395533,0.00003993381,0.000007924835,0.00001515578,0.0001348634,0.0000303468,0.000610689],"genre_scores_gemma":[0.9985996,0.0002819908,0.0003187367,0.00002992112,0.000004079259,0.00001274925,0.0001762308,0.000006039217,0.000570661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002277992,"threshold_uncertainty_score":0.007620692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007780057972762371,"score_gpt":0.2541820066008831,"score_spread":0.2464019486281207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}