{"id":"W4225262207","doi":"10.1161/svin.121.000447","title":"Alteplase Compared to Tenecteplase in patients with Acute Ischemic Stroke (AcT) Trial: Protocol for a Pragmatic Registry linked Randomized Clinical Trial","year":2022,"lang":"en","type":"article","venue":"Stroke Vascular and Interventional Neurology","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of British Columbia; Toronto Western Hospital; London Health Sciences Centre; University of Ottawa; McMaster University; Hamilton Health Sciences; St. Michael's Hospital; Sunnybrook Health Science Centre; Kelowna General Hospital; Western University; University of Toronto; Medicine Hat Regional Hospital; Université de Sherbrooke; Queen's University; University of Calgary; Centre Hospitalier de l’Université de Montréal; Université de Montréal; Red Deer Regional Hospital; Ontario Brain Institute; University of Saskatchewan; Queen Elizabeth II Health Sciences Centre; Grey Nuns Community Hospital; Fraser Health; University of Alberta","funders":"","keywords":"Medicine; Tenecteplase; Thrombolysis; Clinical endpoint; Modified Rankin Scale; Randomized controlled trial; Stroke (engine); Fibrinolytic agent; Clinical trial; Tissue plasminogen activator; Internal medicine; Myocardial infarction; Ischemia; Ischemic stroke","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002227704,0.0003452475,0.001420954,0.0003674867,0.0001251074,0.00003004154,0.0002730133,0.0001323277,0.0002957681],"category_scores_gemma":[0.001126766,0.0002839391,0.0009769133,0.0001782946,0.00019091,0.00007530234,0.0004126551,0.0007200857,0.000004951869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000715419,"about_ca_system_score_gemma":0.0001560187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002291143,"about_ca_topic_score_gemma":0.000009151271,"domain_scores_codex":[0.9955536,0.0009960359,0.001518656,0.0008478976,0.0006330979,0.0004507855],"domain_scores_gemma":[0.9978338,0.000741972,0.0005251722,0.0005337093,0.0001323286,0.0002330197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9722392,0.00303288,0.004451315,0.0001867969,0.001533859,0.00005949661,0.00002621491,0.00004724773,0.00003826278,0.00004409418,0.01801337,0.0003272626],"study_design_scores_gemma":[0.9207104,0.02115442,0.003073263,0.00006863297,0.0007104575,0.00002998634,0.00002014112,0.001293871,0.00002026034,0.00001392584,0.05268229,0.0002223245],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.7997906,0.000009024278,0.001816802,0.001159259,0.0003635148,0.1962029,0.0002522022,0.00005241941,0.0003533488],"genre_scores_gemma":[0.3634067,0.000003031695,0.003352316,0.002371526,0.00036027,0.6278232,0.0008935894,0.0001007759,0.001688615],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4363839,"threshold_uncertainty_score":0.9999613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02567833028889534,"score_gpt":0.3403336122097844,"score_spread":0.3146552819208891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}