{"id":"W4225262207","doi":"10.1161/svin.121.000447","title":"Alteplase Compared to Tenecteplase in patients with Acute Ischemic Stroke (AcT) Trial: Protocol for a Pragmatic Registry linked Randomized Clinical Trial","year":2022,"lang":"en","type":"article","venue":"Stroke Vascular and Interventional Neurology","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of British Columbia; Toronto Western Hospital; London Health Sciences Centre; University of Ottawa; McMaster University; Hamilton Health Sciences; St. Michael's Hospital; Sunnybrook Health Science Centre; Kelowna General Hospital; Western University; University of Toronto; Medicine Hat Regional Hospital; Université de Sherbrooke; Queen's University; University of Calgary; Centre Hospitalier de l’Université de Montréal; Université de Montréal; Red Deer Regional Hospital; Ontario Brain Institute; University of Saskatchewan; Queen Elizabeth II Health Sciences Centre; Grey Nuns Community Hospital; Fraser Health; University of Alberta","funders":"","keywords":"Medicine; Tenecteplase; Thrombolysis; Clinical endpoint; Modified Rankin Scale; Randomized controlled trial; Stroke (engine); Fibrinolytic agent; Clinical trial; Tissue plasminogen activator; Internal medicine; Myocardial infarction; Ischemia; Ischemic stroke","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0299823,0.006270306,0.008910179,0.001491196,0.002861515,0.003889812,0.002928958,0.005893033,0.04476662],"category_scores_gemma":[0.02704703,0.002366326,0.005369172,0.002382074,0.003171864,0.002742487,0.002221827,0.006366683,0.009210027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003539247,"about_ca_system_score_gemma":0.009532983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001776744,"about_ca_topic_score_gemma":0.00348054,"domain_scores_codex":[0.9750539,0.01850416,0.001937783,0.001633952,0.001521505,0.001348704],"domain_scores_gemma":[0.9913066,0.002133927,0.002058485,0.001491259,0.001670042,0.001339765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9499756,0.005250895,0.0006506997,0.009863012,0.002299787,0.0001957923,0.0002395921,0.001277136,0.00139255,0.002869925,0.01508436,0.01090061],"study_design_scores_gemma":[0.9660022,0.01163079,0.001021824,0.001095373,0.0008175036,0.00006969978,0.00006989708,0.001135064,0.0002806606,0.001827483,0.01598443,0.00006499585],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.0048373,0.0005123705,0.00205387,0.0005121505,0.0005960686,0.9869452,0.002646189,0.000120262,0.001776638],"genre_scores_gemma":[0.005160857,0.0002166937,0.002655754,0.0003614827,0.000105495,0.9902635,0.0006236581,0.00001295527,0.0005996275],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04476662,"threshold_uncertainty_score":0.1585634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02567833028889534,"score_gpt":0.3403336122097844,"score_spread":0.3146552819208891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}