{"id":"W4225263020","doi":"10.1371/journal.pone.0267946","title":"DNA methylation profiles in the blood of newborn term infants born to mothers with obesity","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; Biotechnology and Biological Sciences Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"DNA methylation; Differentially methylated regions; Offspring; Body mass index; Longitudinal study; Epigenetics; Childhood obesity; Obesity; CpG site; Biology; Medicine; Genetics; Pregnancy; Physiology; Endocrinology; Gene; Overweight; Pathology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008815535,0.0001404356,0.0002584821,0.00035151,0.0002687512,0.0002694314,0.0001530963,0.0001932933,0.0009867835],"category_scores_gemma":[0.0006511422,0.0001300571,0.0001047562,0.0003219499,0.0001233885,0.00006954087,0.0001675009,0.0002084364,0.0002340233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002807929,"about_ca_system_score_gemma":0.0001451869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01773712,"about_ca_topic_score_gemma":0.01457074,"domain_scores_codex":[0.9999038,0.0000135453,0.000004780552,0.00002734226,0.00002907702,0.00002143833],"domain_scores_gemma":[0.9998616,0.00002688502,0.00003898516,0.00001038558,0.00003246818,0.00002966903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009391693,0.00004819746,0.9348083,0.00003887647,0.00005310607,0.001164787,0.001820426,0.00002766109,0.04968204,0.00002825732,0.0003448203,0.01104438],"study_design_scores_gemma":[0.000002426668,0.00009206062,0.9977728,0.000005295687,0.0000164403,0.0005395461,0.0003549382,0.00003827044,0.0009125417,0.000009365875,0.0002539239,0.000002354121],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990728,0.0002281942,0.00006094292,0.00001931077,0.000003154192,0.00000274644,0.0003105924,0.000003466287,0.0002988061],"genre_scores_gemma":[0.9976414,0.0003981692,0.0001381357,0.0000547823,0.000006067871,0.000015091,0.0005618922,0.000004323929,0.001180089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01773712,"threshold_uncertainty_score":0.03526777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931694364608138,"score_gpt":0.2295857795272945,"score_spread":0.2102688358812131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}