{"id":"W4225270153","doi":"10.7554/elife.76557","title":"Contingency and selection in mitochondrial genome dynamics","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Simons Foundation","keywords":"Mitochondrial DNA; Biology; Genome; Genetics; Evolutionary biology; Model organism; Saccharomyces cerevisiae; Mutant; Computational biology; Yeast; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006666391,0.0001353945,0.0003702339,0.0005130349,0.0006729561,0.001067161,0.0004466959,0.0006103241,0.00153189],"category_scores_gemma":[0.005554861,0.0002544054,0.0002366168,0.0002795233,0.001529566,0.001381815,0.0009536357,0.0006622744,0.0001743712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009532578,"about_ca_system_score_gemma":0.0003436669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001179758,"about_ca_topic_score_gemma":0.001084373,"domain_scores_codex":[0.999683,0.00008514245,0.00001563785,0.0001075983,0.00006257425,0.00004613412],"domain_scores_gemma":[0.9981148,0.001035217,0.0003586176,0.0001948203,0.00009694035,0.0001995971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"observational","study_design_scores_codex":[0.0004428503,0.0001155241,0.08994604,0.0002780104,0.0001538952,0.002291035,0.001281934,0.2813157,0.1200914,0.4524291,0.003283832,0.04837066],"study_design_scores_gemma":[0.00003742958,0.0001174486,0.05227083,0.00003106954,0.00003080964,0.0009215397,0.0006547052,0.6547631,0.00801707,0.2796861,0.003362379,0.0001075773],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624132,0.0006803427,0.02984525,0.00123532,0.00005348865,0.00001038489,0.00009512332,0.000117009,0.005549916],"genre_scores_gemma":[0.9980363,0.000129202,0.001426566,0.00004713921,0.00001420444,0.000006810972,0.00002453067,0.00001145547,0.0003037672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00153189,"threshold_uncertainty_score":0.006916404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006223644549783494,"score_gpt":0.2214078661201095,"score_spread":0.215184221570326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}