{"id":"W4225270990","doi":"10.1038/s41523-022-00425-x","title":"Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer","year":2022,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Cancer Research UK; BC Cancer Agency; QIMR Berghofer Medical Research Institute; Metro North Hospital and Health Service; Department of Foreign Affairs and Trade, Australian Government; Cancer Research Institute","keywords":"SOX10; Biology; Triple-negative breast cancer; Reprogramming; Cancer research; Breast cancer; Phenotype; Neural crest; Genetics; Cancer; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320351,0.0001153288,0.0001778867,0.0002150741,0.0001011904,0.0002396533,0.0000827657,0.0001024159,0.0005203873],"category_scores_gemma":[0.0002755685,0.0001207104,0.0001836078,0.0002054599,0.0001520896,0.00009143373,0.0001763183,0.0001670969,0.0001065362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002821763,"about_ca_system_score_gemma":0.0001401316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001955143,"about_ca_topic_score_gemma":0.003619203,"domain_scores_codex":[0.9999046,0.00001974698,0.000004877383,0.00002415517,0.00002767326,0.00001895618],"domain_scores_gemma":[0.9999096,0.00002337055,0.0000301377,0.00001135433,0.000009978731,0.00001551717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002921454,0.00002158396,0.04806196,0.0000470088,0.00004114042,0.0001597873,0.0001181073,0.001671066,0.9422349,0.0001786438,0.00007116282,0.007102556],"study_design_scores_gemma":[0.00000754003,0.0001872318,0.8186067,0.00000894636,0.00005342108,0.0005613737,0.000263232,0.02418593,0.1545538,0.0004777566,0.001082624,0.00001151502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985738,0.0001163067,0.0009706843,0.000009550294,0.000001396185,0.000003126314,0.0001028951,0.00001907935,0.0002030581],"genre_scores_gemma":[0.9990907,0.00006295928,0.000436927,0.000005537192,5.368169e-7,0.000004514508,0.0001736488,0.000003299397,0.0002218199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001955143,"threshold_uncertainty_score":0.003887534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009202576760837917,"score_gpt":0.257375750146791,"score_spread":0.2481731733859531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}