{"id":"W4225271949","doi":"10.1186/s13048-022-00983-5","title":"Impact of neoadjuvant chemotherapy on somatic mutation status in high-grade serous ovarian carcinoma","year":2022,"lang":"en","type":"article","venue":"Journal of Ovarian Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"University of Toronto; Princess Margaret Cancer Foundation; University Health Network","keywords":"Somatic cell; Medicine; Carboplatin; Chemotherapy; Oncology; Cisplatin; Exome sequencing; Ovarian carcinoma; Internal medicine; Germline mutation; Mutation; Serous carcinoma; Ovarian cancer; Gene; Cancer research; Cancer; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002445238,0.00008562171,0.0002139324,0.0001723882,0.0001269194,0.0002958279,0.00008150114,0.0001370439,0.0007620357],"category_scores_gemma":[0.001134747,0.00004903964,0.0001675043,0.0002166159,0.0001662618,0.0001313526,0.0001342239,0.0001568082,0.00007204518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961315,"about_ca_system_score_gemma":0.0001870709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005600162,"about_ca_topic_score_gemma":0.00156726,"domain_scores_codex":[0.9998504,0.00004546791,0.00002166745,0.00002544979,0.00004055003,0.00001644038],"domain_scores_gemma":[0.9994975,0.0002096746,0.0001528158,0.00002763766,0.00004110069,0.000071184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002598339,0.00007626796,0.9325674,0.0001097252,0.0001213838,0.0009177936,0.00008316238,0.00057696,0.03401921,0.00004844337,0.0001914327,0.02868987],"study_design_scores_gemma":[0.00001669878,0.0006605765,0.9906831,0.00001804923,0.00009656825,0.002352464,0.00009375215,0.0006176511,0.004542001,0.00005349759,0.0008611591,0.000004513689],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984951,0.0008954699,0.000056868,0.00004737906,0.000005350226,0.000003859129,0.00008656908,0.000003096588,0.0004062164],"genre_scores_gemma":[0.9995215,0.0002031857,0.00009257241,0.0000221879,0.000002850903,0.000002621718,0.0001017735,0.000001393909,0.00005199631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007620357,"threshold_uncertainty_score":0.002549291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06048925555328583,"score_gpt":0.3982550185929287,"score_spread":0.3377657630396429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}