{"id":"W4225272646","doi":"10.1101/2022.04.29.490009","title":"MEK inhibitor resistance in lung cancer cells associated with addiction to sustained ERK suppression","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; BC Cancer Foundation; Loxo Oncology; Japanese Respiratory Society; Michael Smith Health Research BC; Memorial Sloan-Kettering Cancer Center; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Trametinib; KRAS; MAPK/ERK pathway; MEK inhibitor; Cancer research; Mutant; Drug resistance; Mutation; Biology; Medicine; Kinase; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090841,0.0001672461,0.0001576905,0.0002179077,0.0001535757,0.0002990385,0.0001137127,0.0001866488,0.00194103],"category_scores_gemma":[0.0001078642,0.00009177563,0.0001304369,0.0001304613,0.0001217887,0.00009692519,0.0001858655,0.0003919756,0.0008441553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001990202,"about_ca_system_score_gemma":0.00008420993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006462323,"about_ca_topic_score_gemma":0.0005334912,"domain_scores_codex":[0.9999249,0.00001455433,0.000008027279,0.0000112497,0.00002508933,0.00001628405],"domain_scores_gemma":[0.999956,0.00001269228,0.000006243373,0.0000104982,0.000005790687,0.000008743326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001482795,0.00003656306,0.001290665,0.00001850339,0.000005417552,0.0002936609,0.000016235,0.0001700949,0.9951789,0.0002935568,0.0002792768,0.002268754],"study_design_scores_gemma":[0.00002153159,0.0002014097,0.009453134,0.000003206795,0.00000709315,0.001842597,0.00003684536,0.002589377,0.9806615,0.0001577842,0.00502087,0.000004643694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918321,0.0005857976,0.002158421,0.0001630568,0.0000298358,0.00002807474,0.0008686203,0.0001490895,0.004185021],"genre_scores_gemma":[0.9921029,0.0002501736,0.0016176,0.0000418615,0.00000631015,0.00001862983,0.0009683114,0.00002581453,0.004968385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00194103,"threshold_uncertainty_score":0.00649339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006057933893116606,"score_gpt":0.2141982714252622,"score_spread":0.2081403375321456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}