{"id":"W4225285790","doi":"10.1021/acs.molpharmaceut.1c00934","title":"Influence of Steric Shield on Biocompatibility and Antithrombotic Activity of Dendritic Polyphosphate Inhibitor","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Biocompatibility; Chemistry; Polyethylene glycol; Cationic polymerization; PEG ratio; Steric effects; Biophysics; Antithrombin; Polyphosphate; Dextran; Biochemistry; Stereochemistry; Heparin; Organic chemistry; Phosphate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003128833,0.0001753427,0.0004099673,0.0001324343,0.00009315128,0.00000729044,0.0001049202,0.00004634932,0.00007249424],"category_scores_gemma":[0.00007980114,0.0001843748,0.0001078368,0.0003687965,0.0001993097,0.00006365158,0.000159661,0.0002341163,0.000001592203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005539196,"about_ca_system_score_gemma":0.0001013358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008833526,"about_ca_topic_score_gemma":0.000001865907,"domain_scores_codex":[0.998518,0.0001464005,0.000356881,0.0002988882,0.0004536502,0.0002261725],"domain_scores_gemma":[0.9991354,0.0001127203,0.0001955377,0.000339683,0.00008362713,0.0001330551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005513413,0.0009471274,0.1374385,0.0006642295,0.0001542923,0.00007355648,0.0006446218,0.003056879,0.8485889,0.0004167588,0.00002371654,0.007440011],"study_design_scores_gemma":[0.001452973,0.0005607122,0.1861322,0.00008470591,0.0001943799,0.00003289404,0.00006150914,0.003760752,0.8073078,0.00009748482,0.0001613782,0.0001532302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974833,0.001405544,0.0001343269,0.0002451646,0.0001127534,0.0004585093,0.00004198691,0.00002999403,0.00008840308],"genre_scores_gemma":[0.9991327,0.00006834316,0.0001995776,0.0005029927,0.00001825924,0.00001227234,0.000008983107,0.00002395545,0.00003294387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04869371,"threshold_uncertainty_score":0.7518588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02423763575905418,"score_gpt":0.3098928608769349,"score_spread":0.2856552251178807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}