{"id":"W4225285790","doi":"10.1021/acs.molpharmaceut.1c00934","title":"Influence of Steric Shield on Biocompatibility and Antithrombotic Activity of Dendritic Polyphosphate Inhibitor","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Biocompatibility; Chemistry; Polyethylene glycol; Cationic polymerization; PEG ratio; Steric effects; Biophysics; Antithrombin; Polyphosphate; Dextran; Biochemistry; Stereochemistry; Heparin; Organic chemistry; Phosphate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446473,0.0002503996,0.0001279136,0.0001098135,0.00007284003,0.000229732,0.0001285059,0.0001880148,0.0004630697],"category_scores_gemma":[0.0003321695,0.0001144048,0.0001074409,0.00009573765,0.0001281043,0.0001998713,0.00009759751,0.0002130441,0.0001340505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001568206,"about_ca_system_score_gemma":0.0001278627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005940206,"about_ca_topic_score_gemma":0.0007001724,"domain_scores_codex":[0.9998727,0.00002088157,0.00001241749,0.00002710055,0.00003452634,0.00003235324],"domain_scores_gemma":[0.9997936,0.00005887681,0.00007015719,0.00001046276,0.00003295177,0.00003403495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001417803,0.00001720146,0.0001389079,0.00002568297,0.000004910543,0.00002299025,0.00001505051,0.000128506,0.9985942,0.00003607776,0.00001660571,0.0008580768],"study_design_scores_gemma":[0.000005799591,0.0002212163,0.001057602,0.00000318077,0.00001454693,0.00003103772,0.000007570125,0.0009440588,0.9972191,0.00000616064,0.0004848451,0.000004905521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982755,0.0005084108,0.0004845175,0.00001429894,0.000005852883,0.000006935334,0.00004334873,0.00001002979,0.0006510979],"genre_scores_gemma":[0.9981439,0.0004155971,0.0007736059,0.00002021013,0.000004396911,0.000009539403,0.00008046995,0.000008303372,0.000543909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005940206,"threshold_uncertainty_score":0.001549125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02423763575905418,"score_gpt":0.3098928608769349,"score_spread":0.2856552251178807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}