{"id":"W4225297234","doi":"10.1038/s41586-022-04638-9","title":"CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":229,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Telesta Therapeutics (Canada); Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cyclin E1; Cancer research; Biology; Synthetic lethality; Olaparib; Cell cycle; Cell; Cyclin; Genetics; DNA repair; DNA; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007238725,0.00008512119,0.00005995219,0.00002793422,0.0001354875,0.00001798148,0.00008576064,0.0002307158,0.0001001979],"category_scores_gemma":[0.00002709896,0.00008292578,0.00003717527,0.00008707957,0.00002714804,0.000001490358,0.00007964433,0.0004727882,0.00000574936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003538361,"about_ca_system_score_gemma":0.00007006242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001211263,"about_ca_topic_score_gemma":0.00001394422,"domain_scores_codex":[0.9993929,0.00002149683,0.00007424265,0.0002554927,0.0001364385,0.0001194631],"domain_scores_gemma":[0.999594,0.000008758375,0.00004964997,0.0002577127,0.00005100284,0.00003885744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000533789,0.0002986493,0.001612442,0.00003673351,0.00007015294,0.00004353962,0.0002677801,0.0009089757,0.873189,0.003225507,0.1120223,0.007791084],"study_design_scores_gemma":[0.0007716584,0.0005260871,0.001756312,0.000009666138,0.00003438292,0.00009327855,0.000187759,0.0000641711,0.3134137,0.0004146714,0.6824369,0.0002913763],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936224,0.001962947,0.0003831641,0.001807993,0.0002042061,0.0001643909,0.0002171907,0.00001152168,0.0016262],"genre_scores_gemma":[0.9959888,0.00007208432,0.0002559867,0.002668745,0.0001782762,0.00005343923,0.0004165242,0.00001784733,0.0003483103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5704146,"threshold_uncertainty_score":0.3381615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00451946968369053,"score_gpt":0.2243244462342273,"score_spread":0.2198049765505368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}