{"id":"W4225297234","doi":"10.1038/s41586-022-04638-9","title":"CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":229,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Telesta Therapeutics (Canada); Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cyclin E1; Cancer research; Biology; Synthetic lethality; Olaparib; Cell cycle; Cell; Cyclin; Genetics; DNA repair; DNA; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855239,0.0004861208,0.0003186742,0.000339169,0.0001382156,0.0002367648,0.0002593587,0.0003489183,0.001457758],"category_scores_gemma":[0.0001647048,0.00017374,0.0002430882,0.0001747517,0.0002713602,0.000127189,0.0002534481,0.0006040438,0.0003348393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003795463,"about_ca_system_score_gemma":0.000193889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004668908,"about_ca_topic_score_gemma":0.0009039587,"domain_scores_codex":[0.9997705,0.00003673119,0.00002337815,0.00004789289,0.00008867573,0.00003294397],"domain_scores_gemma":[0.9998465,0.00004123878,0.00005404847,0.00001721027,0.000008111542,0.00003301611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006759617,0.00002512505,0.00006905611,0.00002745616,0.000005495365,0.00005209205,0.000005635521,0.0003037093,0.9980441,0.0001125514,0.00006861157,0.001218574],"study_design_scores_gemma":[0.00001444272,0.0002738132,0.0006329574,0.000002682774,0.000005301952,0.0002548045,0.000003367138,0.0008087346,0.9964898,0.00002242411,0.001488487,0.00000309837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845088,0.002150816,0.00782602,0.0001791883,0.00006446733,0.0001190018,0.001141489,0.0003210784,0.003689069],"genre_scores_gemma":[0.9916162,0.0009121405,0.003997303,0.00004214291,0.000008258058,0.00007186795,0.0007830922,0.00004358039,0.002525465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001457758,"threshold_uncertainty_score":0.004876673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00451946968369053,"score_gpt":0.2243244462342273,"score_spread":0.2198049765505368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}