{"id":"W4225299292","doi":"10.1101/2022.05.02.490272","title":"Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Dalhousie University","funders":"Dalhousie University; University of Toronto; McMaster University","keywords":"Stress granule; Coronavirus; Biology; Viral replication; Virology; Cell biology; Messenger RNA; Virus; Gene; Translation (biology); Coronavirus disease 2019 (COVID-19); Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264304,0.0003308333,0.0002930064,0.0001358678,0.0001100682,0.0002138021,0.0001085362,0.0002217443,0.001010007],"category_scores_gemma":[0.0001068397,0.0001367725,0.0002947423,0.0001200446,0.0001272773,0.0001192506,0.0001782842,0.0003318916,0.0002499245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001819964,"about_ca_system_score_gemma":0.000159682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006314408,"about_ca_topic_score_gemma":0.0007359336,"domain_scores_codex":[0.9998834,0.00001995343,0.00001249306,0.00002137219,0.00003233734,0.00003043835],"domain_scores_gemma":[0.9998996,0.00002300394,0.00002424124,0.00001360447,0.0000136992,0.00002587655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007325587,0.00001942215,0.0001111576,0.00002604333,0.000004005087,0.00001023056,0.000005688084,0.00002084706,0.9993479,0.00001424519,0.00002169493,0.0003454879],"study_design_scores_gemma":[0.00002221344,0.0005789195,0.01331601,0.000007738061,0.00001192568,0.0001832331,0.00002493069,0.0009482715,0.983035,0.00002304138,0.00184544,0.00000328368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970912,0.001301903,0.0004654029,0.00003615476,0.00001918049,0.00002152075,0.0002849434,0.00003169258,0.000748023],"genre_scores_gemma":[0.9948871,0.000661492,0.001273199,0.00005660245,0.00001097699,0.00003717096,0.001320459,0.00002149875,0.001731503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010007,"threshold_uncertainty_score":0.003378808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744615808868002,"score_gpt":0.2507675570856627,"score_spread":0.2333213989969827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}