{"id":"W4225302747","doi":"10.21203/rs.3.rs-1260415/v1","title":"Volasertib as a monotherapy or in combination with azacitidine in patients with myelodysplastic syndrome, chronic myelomonocytic leukemia, or acute myeloid leukemia: summary of three phase I studies","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Azacitidine; Chronic myelomonocytic leukemia; Myeloid leukemia; Myelodysplastic syndromes; Medicine; Leukemia; Oncology; Cancer research; Internal medicine; Biology; Genetics; Bone marrow; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003206221,0.0009024509,0.002408526,0.0005428737,0.0003614686,0.001172176,0.0006449918,0.0006813772,0.001538733],"category_scores_gemma":[0.001263443,0.0003827676,0.002051086,0.0007667087,0.0003715834,0.0007579799,0.0002759171,0.001717109,0.0002872674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005407442,"about_ca_system_score_gemma":0.001320319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005312716,"about_ca_topic_score_gemma":0.002734641,"domain_scores_codex":[0.9993611,0.0002806262,0.0001211713,0.00008102871,0.00008502181,0.0000710705],"domain_scores_gemma":[0.9990177,0.0003233423,0.0002275108,0.00007243518,0.000120958,0.0002380675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.142923,0.02288515,0.02395741,0.009357592,0.01213623,0.0004315442,0.0007205032,0.003378763,0.09708878,0.0005215339,0.007785091,0.6788144],"study_design_scores_gemma":[0.1688183,0.675712,0.05709067,0.001690514,0.01875727,0.001556422,0.0004361137,0.001415656,0.02653725,0.0005755244,0.0472262,0.0001840593],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7499422,0.2304206,0.002811347,0.001666002,0.0003879466,0.003398899,0.002015037,0.0002816423,0.00907636],"genre_scores_gemma":[0.8663939,0.1185426,0.004210329,0.00245452,0.0005637664,0.001851988,0.00405687,0.0000653906,0.001860679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003206221,"threshold_uncertainty_score":0.01695633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05327081049248705,"score_gpt":0.3852181713232246,"score_spread":0.3319473608307375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}