{"id":"W4225311788","doi":"10.1083/jcb.202109065","title":"Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entry","year":2022,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Cell biology; Mitosis; RHOA; Microtubule; Interphase; Metaphase; Moesin; Radixin; Nocodazole; Ezrin; Cell cortex; Astral microtubules; Cytoskeleton; Mitotic exit; Cell division; Biology; Cell; Chemistry; Spindle apparatus; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005087386,0.0002499507,0.000201446,0.0001643111,0.0002186086,0.0003176229,0.0001282569,0.0001781269,0.001207155],"category_scores_gemma":[0.00007420576,0.000125925,0.0001058292,0.0000727865,0.0001206701,0.000151807,0.000156012,0.0004006636,0.0003564452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002883226,"about_ca_system_score_gemma":0.0001641009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003981527,"about_ca_topic_score_gemma":0.001133919,"domain_scores_codex":[0.9999262,0.000006075251,0.000005376496,0.00001490774,0.00002932032,0.00001808457],"domain_scores_gemma":[0.9999399,0.000008567375,0.00002000719,0.000004531265,0.000007814935,0.00001907574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003747107,0.000004781955,0.0001277989,0.00001373515,7.858614e-7,0.0000307127,0.000003127212,0.00004230168,0.9988247,0.00005996494,0.00002283208,0.0008317336],"study_design_scores_gemma":[0.000004356908,0.00008693548,0.005532416,0.000003099344,0.000003094512,0.0001106127,0.00001768357,0.0005853574,0.99226,0.00003461853,0.001358885,0.000002932833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990766,0.002119737,0.003916659,0.0001782574,0.0000374257,0.0000222753,0.0002846794,0.0001554666,0.002519414],"genre_scores_gemma":[0.9944772,0.0008807273,0.001626269,0.0000453897,0.00001105712,0.00001253812,0.0002081392,0.00001160751,0.00272706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001207155,"threshold_uncertainty_score":0.004038274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125204818666248,"score_gpt":0.245608140427149,"score_spread":0.2343560922404865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}