{"id":"W4225312555","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4806","title":"ATP Citrate Lyase Orchestrates Metabolic and Epigenetic Modifications in Pulmonary Arterial Hypertension","year":2022,"lang":"en","type":"article","venue":"","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"ATP citrate lyase; Epigenetics; Chemistry; Pulmonary hypertension; Biochemistry; Citrate synthase; Enzyme; Internal medicine; Cardiology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002112936,0.0001423428,0.0002318787,0.0001805742,0.0001959746,0.0006377882,0.0002235679,0.0003918615,0.002328427],"category_scores_gemma":[0.0003830456,0.0001962152,0.0002614031,0.0001609832,0.0002438129,0.0002653568,0.0004306115,0.0004051835,0.0003930668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222419,"about_ca_system_score_gemma":0.0002603837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001263523,"about_ca_topic_score_gemma":0.002031008,"domain_scores_codex":[0.9998183,0.00003461816,0.00001162288,0.00004997029,0.00003479491,0.00005066416],"domain_scores_gemma":[0.9998587,0.00002671924,0.00004307504,0.00001434921,0.00003300581,0.00002407027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002916322,0.0001608595,0.04442173,0.0004163308,0.0003774093,0.000682442,0.0005432107,0.0008970111,0.8898312,0.004215739,0.002354532,0.05318314],"study_design_scores_gemma":[0.000222674,0.0009707086,0.6439179,0.0001863712,0.0005275115,0.001492087,0.001594704,0.00645498,0.2960364,0.006440444,0.04205058,0.0001055504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.95654,0.02394445,0.009109015,0.001990055,0.0004100748,0.00003683263,0.001288128,0.0001782072,0.006503289],"genre_scores_gemma":[0.9919749,0.002766107,0.0008298877,0.0002656166,0.00005852534,0.00002004523,0.0004519004,0.00001854222,0.003614464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002328427,"threshold_uncertainty_score":0.007789373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04839868888322524,"score_gpt":0.2855182195285664,"score_spread":0.2371195306453411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}