{"id":"W4225313464","doi":"10.1096/fasebj.2022.36.s1.0r878","title":"Colonic Goblet Cells Produce Augmented Levels of Pro‐inflammatory Cytokines due to Metabolically Stressful MUC2 Mucin Biosynthesis","year":2022,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Amoebic Infections and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Mucin; Mucus; Goblet cell; Mucin 2; Innate immune system; Cell biology; Biology; Chemokine; Proinflammatory cytokine; Immunology; Microbiology; Inflammation; Immune system; Epithelium; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416807,0.0003983401,0.0003992848,0.0002504741,0.0001454875,0.0004037955,0.00008988549,0.0004687358,0.002183636],"category_scores_gemma":[0.0001634856,0.0001567961,0.000356133,0.0002012988,0.0002682086,0.0003147697,0.0002480063,0.0007765404,0.0004090899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001847379,"about_ca_system_score_gemma":0.0001408304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003415708,"about_ca_topic_score_gemma":0.0006051178,"domain_scores_codex":[0.9997769,0.00002516051,0.00002287131,0.00004971885,0.00006665324,0.00005870247],"domain_scores_gemma":[0.9998112,0.00002263074,0.00005721819,0.00002498729,0.00002236049,0.0000615749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001122285,0.000008669812,0.0002248556,0.00004659501,0.000002951471,0.00005670523,0.00001208996,0.00001542984,0.9992899,0.00001048866,0.0000132623,0.0002069094],"study_design_scores_gemma":[0.00003529765,0.0009850945,0.04107935,0.0000185262,0.00003291584,0.000623651,0.0002767387,0.0005451626,0.9543846,0.00007911966,0.001924257,0.00001529164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956216,0.0009918406,0.001520653,0.0001534262,0.00004344101,0.00002803318,0.0008110557,0.00008076794,0.0007491702],"genre_scores_gemma":[0.9929576,0.000780494,0.002180643,0.0001585436,0.00001778808,0.00007917301,0.001183347,0.00002360479,0.002618989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002183636,"threshold_uncertainty_score":0.007305026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01928552331125281,"score_gpt":0.258662948179471,"score_spread":0.2393774248682182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}