{"id":"W4225318464","doi":"10.1007/s00018-022-04287-1","title":"Impaired regulation of PMCA activity by defective CFTR expression promotes epithelial cell damage in alcoholic pancreatitis and hepatitis","year":2022,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Szent-Györgyi Albert Orvostudományi Kar, Szegedi Tudományegyetem; Horizon 2020; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; McGill University; Medizinischen Hochschule Hannover; Magyar Tudományos Akadémia","keywords":"Intracellular; Cholangiocyte; Pancreatitis; Alcoholic liver disease; Cell biology; Cystic fibrosis transmembrane conductance regulator; Alcoholic hepatitis; Taurocholic acid; Internal medicine; Endocrinology; Biology; Chemistry; Cancer research; Cystic fibrosis; Medicine; Bile acid; Cirrhosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003511431,0.0001259783,0.0002712894,0.0001289012,0.0002397617,0.000009461215,0.00005499386,0.00005388962,0.00004353612],"category_scores_gemma":[0.00006163415,0.0001114859,0.00004443217,0.0002336413,0.0003733883,0.00009373686,0.00009878458,0.0001108443,5.455523e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003044377,"about_ca_system_score_gemma":0.00008916618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005392284,"about_ca_topic_score_gemma":0.00001600799,"domain_scores_codex":[0.9987893,0.0002696387,0.0001519137,0.0003633091,0.0002440277,0.0001817943],"domain_scores_gemma":[0.9995901,0.00005439621,0.0001021069,0.0001333578,0.00002176933,0.00009827958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004591794,0.000172226,0.1851313,0.00003164092,0.00001053941,0.00008865089,0.000496263,0.00001091675,0.8132919,0.00005728646,0.00002665579,0.0006366735],"study_design_scores_gemma":[0.00116192,0.0008013841,0.2403083,0.00003868786,0.00005855616,0.00004198251,0.0001272081,0.0005195654,0.7564313,0.0003460888,0.00005886014,0.0001061242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952772,0.002880872,0.0003643059,0.0001174394,0.00003865034,0.0004077082,0.00004586245,0.00001439453,0.0008535309],"genre_scores_gemma":[0.9988825,0.0002412889,0.0006249644,0.00006424953,0.000008851579,0.000060844,0.00003185026,0.000007771185,0.00007767812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05686059,"threshold_uncertainty_score":0.4546261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009445279552934997,"score_gpt":0.2401026426611029,"score_spread":0.2306573631081679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}