{"id":"W4225319381","doi":"10.1111/all.15315","title":"Methylation risk scores for childhood aeroallergen sensitization: Results from the LISA birth cohort","year":2022,"lang":"en","type":"article","venue":"Allergy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"H2020 European Research Council; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie; Helmholtz-Zentrum für Umweltforschung; Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München; Deutscher Akademischer Austauschdienst","keywords":"Aeroallergen; dNaM; Medicine; Allergy; DNA methylation; Sensitization; Biomarker; Confidence interval; Atopy; Asthma; Immunology; Prospective cohort study; Cohort; Internal medicine; Genetics; Allergen; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00161814,0.0004212702,0.0004668995,0.001252789,0.0004266221,0.0007879235,0.0005011834,0.0004811459,0.002977053],"category_scores_gemma":[0.002594061,0.0003737098,0.001098881,0.00117755,0.0002889126,0.0002485922,0.001046362,0.0005887572,0.0006327086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005718927,"about_ca_system_score_gemma":0.0004372089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01740837,"about_ca_topic_score_gemma":0.01766308,"domain_scores_codex":[0.99931,0.0001338805,0.00005017787,0.0002745319,0.0001408653,0.00009061186],"domain_scores_gemma":[0.9984552,0.0003104045,0.0004891683,0.0003227666,0.0002011725,0.000221257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003967644,0.00001732787,0.9949391,0.00003530004,0.0004261076,0.00009522136,0.0001469699,0.0001601014,0.00082559,0.00004702736,0.0005383428,0.002372077],"study_design_scores_gemma":[0.000008692481,0.00004060882,0.9989756,0.000008386436,0.0001592821,0.00007773902,0.00006121833,0.0001545872,0.0001247481,0.00001638004,0.0003683104,0.000004399228],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913031,0.0005329571,0.0003209041,0.00008346692,0.000009402252,0.000009395241,0.007041394,0.00003592611,0.0006634166],"genre_scores_gemma":[0.9939494,0.0002557487,0.0002651292,0.00004173425,0.000009915571,0.0000231813,0.004865684,0.00002324226,0.0005660444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01740837,"threshold_uncertainty_score":0.03461409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009103806048315979,"score_gpt":0.2269069252392984,"score_spread":0.2178031191909824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}