{"id":"W4225319381","doi":"10.1111/all.15315","title":"Methylation risk scores for childhood aeroallergen sensitization: Results from the LISA birth cohort","year":2022,"lang":"en","type":"article","venue":"Allergy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"H2020 European Research Council; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie; Helmholtz-Zentrum für Umweltforschung; Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München; Deutscher Akademischer Austauschdienst","keywords":"Aeroallergen; dNaM; Medicine; Allergy; DNA methylation; Sensitization; Biomarker; Confidence interval; Atopy; Asthma; Immunology; Prospective cohort study; Cohort; Internal medicine; Genetics; Allergen; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004785996,0.0001298341,0.000107264,0.0000237738,0.0005013013,0.00002903517,0.0001900564,0.00007239953,0.00009183786],"category_scores_gemma":[0.0003199043,0.0001118841,0.000102322,0.0001054306,0.00002890489,0.00000334377,0.0001590913,0.00009072755,0.00000306693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000165824,"about_ca_system_score_gemma":0.00006131786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003543138,"about_ca_topic_score_gemma":0.0004935188,"domain_scores_codex":[0.9987433,0.0002217058,0.0002693088,0.0003977778,0.0001974012,0.0001705391],"domain_scores_gemma":[0.9990875,0.0001495573,0.0001935527,0.0004359599,0.00008939912,0.00004399987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002668199,0.0007426314,0.07839899,0.00001520506,0.003377154,0.000005541595,0.003495511,0.2805566,0.4982956,0.002407413,0.07401124,0.05602591],"study_design_scores_gemma":[0.002481133,0.0005484573,0.2400302,0.00000494992,0.00007027621,0.000001574963,0.0001777523,0.003837133,0.08654913,0.003221312,0.6626371,0.0004409933],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828761,0.003381815,0.008845511,0.001381804,0.0004971799,0.0006001175,0.001176271,0.00002155256,0.001219676],"genre_scores_gemma":[0.9905691,0.001342129,0.0009889515,0.00027533,0.0006698575,0.0001159454,0.00514066,0.00003114803,0.0008668975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5886258,"threshold_uncertainty_score":0.4562502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009103806048315979,"score_gpt":0.2269069252392984,"score_spread":0.2178031191909824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}