{"id":"W4225326271","doi":"10.1096/fasebj.2022.36.s1.0i112","title":"Proximity‐dependent sensors for signaling","year":2022,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Terry Fox Research Institute; Kidney Foundation of Canada","keywords":"Biotinylation; Endosome; Organelle; Computational biology; Cell biology; Biology; Intracellular; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007360714,0.0006683707,0.0004893176,0.0004481462,0.0005760218,0.00115862,0.0008426945,0.001246211,0.004414393],"category_scores_gemma":[0.0008194771,0.0004119097,0.0004066822,0.0003778513,0.0009616856,0.002211173,0.001537072,0.003015159,0.002262262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001095376,"about_ca_system_score_gemma":0.0003563732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002174308,"about_ca_topic_score_gemma":0.0003703587,"domain_scores_codex":[0.9993454,0.0001206145,0.00003363711,0.0001606426,0.0002819709,0.00005774837],"domain_scores_gemma":[0.9997579,0.00007960675,0.00003494001,0.00004766383,0.00004496019,0.00003498306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009933231,0.00004263788,0.0001482891,0.0005560139,0.00002165077,0.0001079149,0.0001670809,0.0007543761,0.8315563,0.118117,0.004869243,0.04356027],"study_design_scores_gemma":[0.00003602943,0.0002081053,0.0004113287,0.0001022138,0.00002653,0.0006977673,0.0001143771,0.006162237,0.6473225,0.03288346,0.3119653,0.00007018039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.0959638,0.1720858,0.6285263,0.01366268,0.004566037,0.0004532312,0.001301086,0.003224652,0.08021636],"genre_scores_gemma":[0.5705175,0.08500234,0.2949065,0.004119286,0.001600872,0.0007603004,0.001165394,0.0003593981,0.04156838],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004414393,"threshold_uncertainty_score":0.01476759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430089746116257,"score_gpt":0.2425929609049723,"score_spread":0.2282920634438098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}