{"id":"W4225326271","doi":"10.1096/fasebj.2022.36.s1.0i112","title":"Proximity‐dependent sensors for signaling","year":2022,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Terry Fox Research Institute; Kidney Foundation of Canada","keywords":"Biotinylation; Endosome; Organelle; Computational biology; Cell biology; Biology; Intracellular; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004803907,0.00006959508,0.00006490618,0.00001699663,0.0009154045,0.00002103941,0.0001696014,0.00003463722,0.00004693426],"category_scores_gemma":[0.00002885034,0.00004453299,0.0001045111,0.00003355286,0.0000388416,0.000001087039,0.0001245194,0.0002518052,0.000002006316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001498933,"about_ca_system_score_gemma":0.0000385005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001155538,"about_ca_topic_score_gemma":8.386108e-7,"domain_scores_codex":[0.9994016,0.00008873671,0.0001190916,0.00009916173,0.0001239752,0.0001673915],"domain_scores_gemma":[0.9997327,0.00001455188,0.00007671127,0.0001004012,0.00004058711,0.00003500295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001258467,0.00003674783,0.0001766719,0.000004456486,0.000167038,0.000007016739,0.0001983439,0.002364982,0.9908245,0.00007612052,0.00521705,0.000801253],"study_design_scores_gemma":[0.0009768268,0.0005612743,0.00006722433,0.00000570359,0.00007139741,0.0008342083,0.002580592,0.0001862479,0.9392429,0.0004783284,0.05482023,0.0001750473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943305,0.001840648,0.0009718323,0.001445099,0.0005383797,0.0001915075,0.00002356608,0.000006275368,0.0006521837],"genre_scores_gemma":[0.9958792,0.000131171,0.000231189,0.0003247178,0.0003927635,0.00001642055,0.000008414789,0.00001114761,0.003004948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05158155,"threshold_uncertainty_score":0.7040644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430089746116257,"score_gpt":0.2425929609049723,"score_spread":0.2282920634438098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}