{"id":"W4225327726","doi":"10.1016/j.nbd.2022.105740","title":"Altered cortical processing of sensory input in Huntington disease mouse models","year":2022,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Lethbridge; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Hereditary Disease Foundation","keywords":"Neuroscience; Sensory system; Huntington's disease; Local field potential; Stimulation; Striatum; Cortex (anatomy); Excitatory postsynaptic potential; Sensory cortex; Ex vivo; Electrophysiology; Cortical neurons; Sensory processing; Psychology; Biology; In vivo; Medicine; Disease; Pathology; Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002132105,0.0009926074,0.0004397287,0.001446782,0.0002856015,0.0005722356,0.0004630847,0.0006494989,0.003267923],"category_scores_gemma":[0.0001983091,0.0003720601,0.0003594178,0.0003343643,0.0006714294,0.0003954762,0.0005261608,0.001321253,0.0005744923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004956271,"about_ca_system_score_gemma":0.000256498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101975,"about_ca_topic_score_gemma":0.001935273,"domain_scores_codex":[0.9997516,0.00002457958,0.00003110298,0.0000769093,0.0000789168,0.0000368227],"domain_scores_gemma":[0.9997376,0.00005532163,0.00007821753,0.00003217071,0.00002587261,0.00007083779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000096624,0.00003444571,0.0001584274,0.00003123563,0.00001176283,0.0001382124,0.00002442818,0.00008678591,0.9984876,0.000105339,0.00005459329,0.0007704684],"study_design_scores_gemma":[0.00005432201,0.000484014,0.01837564,0.00003204883,0.00005655807,0.001231531,0.0001046178,0.001693537,0.9753684,0.0003435048,0.002236994,0.00001893169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848856,0.0009396404,0.007921004,0.0001693448,0.00006237244,0.00008683183,0.002710469,0.0004655933,0.002759028],"genre_scores_gemma":[0.9794797,0.001133893,0.007958725,0.0001462628,0.00001189055,0.0003158526,0.001972227,0.000184115,0.008797277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003267923,"threshold_uncertainty_score":0.01093227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0421996350988826,"score_gpt":0.2752887586163729,"score_spread":0.2330891235174903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}