{"id":"W4225331163","doi":"10.1016/j.antiviral.2022.105328","title":"In vitro activity of letermovir against human cytomegalovirus isolates with different drug susceptibility phenotypes","year":2022,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Merck Canada","keywords":"Human cytomegalovirus; Biology; Virology; Recombinant DNA; Polymerase; Sanger sequencing; DNA polymerase; Mutation; Virus; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004520613,0.0006241796,0.0004261736,0.0003916705,0.0002467518,0.0004499599,0.0003451079,0.0003705639,0.001873537],"category_scores_gemma":[0.0007571941,0.0001831866,0.0004737443,0.0003912859,0.000260935,0.0002322641,0.000251902,0.0005351563,0.0005766508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002460848,"about_ca_system_score_gemma":0.0002602713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001865953,"about_ca_topic_score_gemma":0.001632114,"domain_scores_codex":[0.9995732,0.0001791463,0.0000551033,0.00004927929,0.00006214088,0.00008125851],"domain_scores_gemma":[0.9995735,0.0002369301,0.00003611012,0.00005114833,0.00005105399,0.00005131181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002572936,0.0003312454,0.001190078,0.0002063892,0.00006373926,0.0001577962,0.0001249927,0.0008129321,0.9896961,0.0001236409,0.0001962821,0.004523919],"study_design_scores_gemma":[0.00007432626,0.003830983,0.004922822,0.00001766972,0.00006664819,0.0002550285,0.00006414177,0.0006469829,0.9887782,0.0000342017,0.00129603,0.00001301728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898514,0.005949507,0.0009181596,0.00006134706,0.0001108642,0.00004049198,0.0009552618,0.00003485231,0.002078094],"genre_scores_gemma":[0.9921868,0.002173341,0.001233467,0.00005047846,0.00004201298,0.00003021675,0.002429877,0.00001487398,0.001838934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001873537,"threshold_uncertainty_score":0.006267548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05244458202467387,"score_gpt":0.3669147286514559,"score_spread":0.314470146626782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}