{"id":"W4225346755","doi":"10.21203/rs.3.rs-1154862/v1","title":"Single Extracellular Vesicles (EV) Proteomic Profiling Altered and Identifies Co-Localization of SARS-CoV-2 Nucleocapsid Protein with CD81/Integrin-Rich EV Subpopulation in Sputum Samples of COVID-19 Patients","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Optech (Canada)","funders":"Guangdong Provincial Pearl River Talents Program; National Natural Science Foundation of China; State Key Laboratory of Respiratory Disease","keywords":"CD81; Extracellular vesicles; Sputum; Virology; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Integrin; Biology; Tetraspanin; Immunology; Cell biology; Medicine; Cell; Virus; Pathology; Biochemistry; Tuberculosis; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135202,0.0002444406,0.000289517,0.0004768137,0.0002822996,0.0006816952,0.0001329089,0.0005045754,0.001383314],"category_scores_gemma":[0.000339328,0.00013308,0.0002914623,0.0002566629,0.0001671294,0.0001788729,0.0003373081,0.0003222159,0.0003492163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001411886,"about_ca_system_score_gemma":0.0001035971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006713268,"about_ca_topic_score_gemma":0.0005350571,"domain_scores_codex":[0.9998103,0.000014732,0.00002236026,0.00005605368,0.0000439826,0.00005255601],"domain_scores_gemma":[0.9999112,0.00001661805,0.00002079065,0.000006913072,0.00002175634,0.00002269856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001973861,0.0001052548,0.3239454,0.0001912558,0.0001528428,0.004945403,0.0005035788,0.000175695,0.6536729,0.0002375571,0.001145344,0.01295092],"study_design_scores_gemma":[0.00003076685,0.0003493658,0.8949642,0.00004266132,0.0001458379,0.01202242,0.001030483,0.001314282,0.0865325,0.0002665728,0.003283631,0.00001735722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976794,0.0006122487,0.0002806864,0.0000672424,0.00002195104,0.000009317871,0.0008811523,0.00001459744,0.0004334095],"genre_scores_gemma":[0.9978503,0.0001992052,0.0002861918,0.00005967249,0.00001376809,0.000008311488,0.0009782042,0.000008038864,0.0005963179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001383314,"threshold_uncertainty_score":0.004627585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07041950028293868,"score_gpt":0.3665957891737865,"score_spread":0.2961762888908478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}