{"id":"W4225350183","doi":"10.1101/2022.01.05.475077","title":"Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Ontario Institute for Cancer Research; University of Toronto","funders":"Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; McGill University; Genentech; Government of Ontario; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Small molecule; Nucleosome; Histone H3; Histone; PRC2; Histone deacetylase; PHD finger; Biology; Chemistry; Cell biology; Computational biology; Biochemistry; Transcription factor; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001909777,0.0004264727,0.0003897369,0.0002928469,0.0001651742,0.0003647126,0.0003875537,0.0003203618,0.002747442],"category_scores_gemma":[0.0001308424,0.0001772362,0.0003070713,0.0001455595,0.0001574924,0.0001198527,0.0002169247,0.0006865531,0.0009286175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004464028,"about_ca_system_score_gemma":0.0002910327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006990859,"about_ca_topic_score_gemma":0.001627939,"domain_scores_codex":[0.9999238,0.0000122726,0.000003680701,0.00001240628,0.00002524695,0.00002252103],"domain_scores_gemma":[0.9999554,0.000007428524,0.000008666952,0.000003441353,0.000009221103,0.00001579674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007321488,0.0002297396,0.0004927738,0.000154307,0.0001020193,0.0002011073,0.00002322026,0.001259459,0.9737017,0.001123131,0.002431727,0.01954867],"study_design_scores_gemma":[0.0008621815,0.002967836,0.001762102,0.00002333645,0.0001529522,0.0006665461,0.00002783758,0.004529078,0.9425817,0.0003071844,0.04609498,0.0000242153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9386839,0.02101189,0.02035793,0.001327165,0.0005458777,0.0005763086,0.002832138,0.0007103564,0.0139544],"genre_scores_gemma":[0.9563656,0.006894288,0.01108568,0.000572716,0.00006845148,0.0002484966,0.003311012,0.0000636699,0.02139017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002747442,"threshold_uncertainty_score":0.009191096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484357107534883,"score_gpt":0.2294184284200154,"score_spread":0.2145748573446665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}