{"id":"W4225352300","doi":"10.2337/db21-0800","title":"Mitofusins <i>Mfn1</i> and <i>Mfn2</i> Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion","year":2022,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology and Biological Sciences Research Council; National Institutes of Health; Diabetes UK; Medical Research Council; Steno Diabetes Center Copenhagen; Academy of Medical Sciences; Wellcome Trust; National Institute for Health and Care Research; Melanoma Research Alliance; U.S. Department of Veterans Affairs","keywords":"MFN2; Incretin; MFN1; Diabetes mellitus; Cell biology; Biology; Endocrinology; Type 2 diabetes; Genetics; mitochondrial fusion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195036,0.0004198646,0.0002713933,0.0002422878,0.0002404502,0.0002941245,0.0002495504,0.00039992,0.001445498],"category_scores_gemma":[0.0001462772,0.000149317,0.0002295934,0.000102643,0.0003319242,0.0003303394,0.0003168541,0.0006235134,0.000384274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002645968,"about_ca_system_score_gemma":0.0001612414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004060467,"about_ca_topic_score_gemma":0.0007849165,"domain_scores_codex":[0.9998873,0.00001058484,0.00001657722,0.00003582002,0.00002927387,0.0000203776],"domain_scores_gemma":[0.999755,0.00002021501,0.0001081767,0.00001826149,0.00001460716,0.00008372158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001016969,0.000008115656,0.0001452043,0.00001654735,0.000002345175,0.00004460496,0.000008044095,0.00002192866,0.9990253,0.0001234104,0.00002327534,0.0004795133],"study_design_scores_gemma":[0.00003205862,0.0001191134,0.01281504,0.00001875281,0.00001965634,0.0008444466,0.00005583556,0.0007161038,0.9798113,0.0001611,0.005394499,0.00001221449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921182,0.001000739,0.004181995,0.0002016519,0.00003961176,0.00002650217,0.0009776196,0.0001393459,0.00131436],"genre_scores_gemma":[0.9929717,0.000560811,0.003375409,0.00009499647,0.00002096202,0.0000549464,0.0008763549,0.00008556995,0.001959312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445498,"threshold_uncertainty_score":0.004835665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531705487561426,"score_gpt":0.2297023987509491,"score_spread":0.2143853438753348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}