{"id":"W4225352300","doi":"10.2337/db21-0800","title":"Mitofusins <i>Mfn1</i> and <i>Mfn2</i> Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion","year":2022,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology and Biological Sciences Research Council; National Institutes of Health; Diabetes UK; Medical Research Council; Steno Diabetes Center Copenhagen; Academy of Medical Sciences; Wellcome Trust; National Institute for Health and Care Research; Melanoma Research Alliance; U.S. Department of Veterans Affairs","keywords":"MFN2; Incretin; MFN1; Diabetes mellitus; Cell biology; Biology; Endocrinology; Type 2 diabetes; Genetics; mitochondrial fusion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004837774,0.0002760599,0.0005605545,0.0001887224,0.0003425457,0.00005745269,0.00009050021,0.0001067202,0.0002404316],"category_scores_gemma":[0.0007672325,0.0002748476,0.00007176284,0.0004122377,0.0001098136,0.0001343916,0.0003268692,0.0003039351,0.00002322218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008899478,"about_ca_system_score_gemma":0.00006574798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001203237,"about_ca_topic_score_gemma":0.000003499327,"domain_scores_codex":[0.9980477,0.0002255346,0.000326884,0.0005789365,0.0003862111,0.0004347483],"domain_scores_gemma":[0.998434,0.0005385602,0.000149264,0.0003674999,0.0001260109,0.0003846801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000564219,0.0002872349,0.1968035,0.0002779848,0.00008339494,0.00002050777,0.0004187237,0.00005710667,0.796797,0.0000435,0.00303757,0.001609282],"study_design_scores_gemma":[0.009346882,0.002361716,0.2795109,0.0002294114,0.0004162575,0.00002239036,0.001186304,0.01055186,0.6775973,0.0002831745,0.01766044,0.0008332857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993345,0.002100977,0.00001403448,0.001682358,0.0002324676,0.0007785312,0.0002363479,0.0001954626,0.001414881],"genre_scores_gemma":[0.9936309,0.00008023317,0.0002771877,0.004893707,0.0001188026,0.000152223,0.0001476937,0.00004374186,0.0006555294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1191996,"threshold_uncertainty_score":0.9999704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531705487561426,"score_gpt":0.2297023987509491,"score_spread":0.2143853438753348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}