{"id":"W4225374410","doi":"10.1101/2022.05.02.490213","title":"FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Tsinghua University; National Natural Science Foundation of China; University of Calgary","keywords":"FOXP3; Ryanodine receptor; Immune system; Cell biology; Immunology; Effector; IL-2 receptor; Autoimmunity; Ryanodine receptor 2; Immunoediting; Biology; Chemistry; T cell; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002248559,0.000304794,0.0002657576,0.0002219666,0.0002730156,0.0004615341,0.0001832615,0.0005127896,0.01124103],"category_scores_gemma":[0.0003401597,0.0001245343,0.0002023236,0.0001068402,0.0002322692,0.0002243877,0.0001933943,0.000578576,0.004832961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002294109,"about_ca_system_score_gemma":0.000245659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002176733,"about_ca_topic_score_gemma":0.0002787617,"domain_scores_codex":[0.9998695,0.00001114482,0.000006503987,0.00002307866,0.00007443625,0.00001535989],"domain_scores_gemma":[0.9998732,0.0000299348,0.00002206101,0.00001335364,0.00003038406,0.0000311184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004758363,0.00004819068,0.000438837,0.0002796668,0.00002222534,0.0009605808,0.00004132109,0.0002352961,0.9244801,0.00583765,0.04747785,0.01970242],"study_design_scores_gemma":[0.0001461226,0.000235891,0.007831272,0.0000472643,0.00003379512,0.001739825,0.00005657109,0.004010458,0.8180478,0.005270814,0.1625532,0.00002710203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6196803,0.02808689,0.09884104,0.04289132,0.06244365,0.0003737861,0.006216438,0.006486456,0.1349801],"genre_scores_gemma":[0.7475938,0.005702029,0.009690939,0.001883291,0.008485521,0.0001143566,0.002491645,0.0008153915,0.2232231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01124103,"threshold_uncertainty_score":0.03760493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00812487100105155,"score_gpt":0.1999204712409978,"score_spread":0.1917956002399462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}