{"id":"W4225377465","doi":"10.1096/fasebj.2022.36.s1.r2780","title":"Discovery of Novel Pain Therapies Without Side‐effects by Combining Targeted Mutagenesis and Phenotype‐based Drug Screening in Larval Zebrafish","year":2022,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Public Health Ontario; Toronto Public Health","funders":"","keywords":"Fentanyl; Zebrafish; Opioid; Pharmacology; Addiction; Medicine; Drug discovery; Drug; Adenylyl cyclase; Bioinformatics; Biology; Psychiatry; Internal medicine; Genetics; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004257644,0.0009981699,0.0005330576,0.000690156,0.0003334568,0.0004294505,0.000701645,0.0006708881,0.001916942],"category_scores_gemma":[0.0001639954,0.0003947547,0.0007988358,0.0002337586,0.0005353017,0.0004127121,0.000521267,0.0009975662,0.0005881999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001358518,"about_ca_system_score_gemma":0.0009811574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004741157,"about_ca_topic_score_gemma":0.009852414,"domain_scores_codex":[0.9997235,0.00002212504,0.00002453516,0.00005477801,0.0001292258,0.00004580892],"domain_scores_gemma":[0.9999126,0.00001379427,0.00003008332,0.000008667532,0.00001785331,0.00001701628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002390642,0.00001842455,0.0001200544,0.00006029443,0.000009855277,0.00004708466,0.000006000517,0.0002886351,0.9968604,0.0002589261,0.000148167,0.002158258],"study_design_scores_gemma":[0.00007964483,0.0006717442,0.002272989,0.00002665301,0.00007714769,0.0003381671,0.00002482669,0.004092659,0.9845647,0.0002106424,0.00761244,0.0000284075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7715682,0.00874072,0.1844079,0.003093073,0.0003349628,0.001705897,0.007736002,0.003890997,0.01852218],"genre_scores_gemma":[0.8435258,0.009052173,0.1270518,0.0009225404,0.00003813427,0.001197405,0.002875784,0.0002978619,0.01503853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004741157,"threshold_uncertainty_score":0.00985682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123420476604779,"score_gpt":0.2573911891122174,"score_spread":0.2461569843461696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}