{"id":"W4225388109","doi":"10.2147/jaa.s355391","title":"Rapid and Continuing Improvements in Nasal Symptoms with Dupilumab in Patients with Severe CRSwNP","year":2022,"lang":"en","type":"article","venue":"Journal of Asthma and Allergy","topic":"Sinusitis and nasal conditions","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Covis Pharma; Regeneron Pharmaceuticals; Sanofi; AstraZeneca; Amgen; Pfizer; Mylan; GlaxoSmithKline","keywords":"Medicine; Dupilumab; Nasal polyps; Clinical endpoint; Placebo; Chronic rhinosinusitis; Confidence interval; Odds ratio; Post-hoc analysis; Internal medicine; Gastroenterology; Sinus (botany); Nasal congestion; Nasal administration; Randomized controlled trial; Nose; Surgery; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309702,0.00008820304,0.00023558,0.0002022246,0.00005076228,0.00001597451,0.00003337485,0.00002047452,0.0001604405],"category_scores_gemma":[0.000008505792,0.00006323637,0.00001945496,0.0001416028,0.00003038175,0.0001234605,0.00003667679,0.000255726,1.394126e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005053542,"about_ca_system_score_gemma":0.00004610384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002521694,"about_ca_topic_score_gemma":0.0000545267,"domain_scores_codex":[0.9992227,0.00003353206,0.0002389936,0.0001047567,0.0002632776,0.0001367315],"domain_scores_gemma":[0.999622,0.00002203256,0.0001532514,0.00005129347,0.00006794634,0.0000834832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003978213,0.000605415,0.9390751,0.00002637523,0.0001591575,0.0007048299,0.001230885,0.00004447162,0.0002968053,0.00005726981,0.0002952401,0.05352628],"study_design_scores_gemma":[0.01405357,0.004929437,0.9780413,0.000227053,0.00001103643,0.0003874311,0.0007092256,0.0000337215,0.00001360825,0.000008792358,0.001496937,0.00008792229],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999098,0.0003369843,0.000004669752,0.0001394968,0.00004401878,0.0001143923,0.000006699235,0.000002261031,0.0002534924],"genre_scores_gemma":[0.9994808,0.00003447907,0.0001246062,0.0002079814,0.00003262909,0.000004120303,0.000007113067,0.00001087249,0.00009735685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05343836,"threshold_uncertainty_score":0.2578704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003371542923866057,"score_gpt":0.1947153225204501,"score_spread":0.191343779596584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}