{"id":"W4225391630","doi":"10.1089/hum.2022.023","title":"Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles","year":2022,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Fibrodysplasia ossificans progressiva; Heterotopic ossification; Genetic enhancement; Endochondral ossification; Medicine; Disease; Heterotopic bone; Bioinformatics; Gene; Pathology; Biology; Surgery; Genetics; Anatomy; Cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006367253,0.0005040031,0.001066153,0.001332424,0.0002111168,0.0009560753,0.0006422104,0.001101844,0.002449177],"category_scores_gemma":[0.0006249305,0.0001874309,0.0005162624,0.001126992,0.000478196,0.001054681,0.0004573275,0.001567391,0.001150142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000383323,"about_ca_system_score_gemma":0.0006107434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006458702,"about_ca_topic_score_gemma":0.001104185,"domain_scores_codex":[0.9998351,0.00003672082,0.00002261471,0.00002777818,0.00006328924,0.00001435978],"domain_scores_gemma":[0.9997367,0.0001716884,0.00002503614,0.000008265512,0.00004410176,0.00001423609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008301922,0.00009438385,0.0001259357,0.01647404,0.00006701931,0.0003625245,0.00009707356,0.0003749934,0.003328394,0.007535314,0.01600741,0.9554499],"study_design_scores_gemma":[0.0000263812,0.0001619669,0.0005744259,0.004487752,0.0001043229,0.002866993,0.00008479924,0.0001527991,0.001307366,0.003138832,0.9870754,0.00001888312],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001335393,0.9990004,0.00009023975,0.0001486511,0.00007540215,0.000002124712,0.000005632824,0.0000029884,0.0005410509],"genre_scores_gemma":[0.0008336037,0.9983565,0.0001670436,0.0001294203,0.00006717839,0.000004807463,0.00001115654,0.000001346957,0.0004289246],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002449177,"threshold_uncertainty_score":0.008193314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2544577392098565,"score_gpt":0.425163469258499,"score_spread":0.1707057300486425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}