{"id":"W4225391630","doi":"10.1089/hum.2022.023","title":"Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles","year":2022,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Fibrodysplasia ossificans progressiva; Heterotopic ossification; Genetic enhancement; Endochondral ossification; Medicine; Disease; Heterotopic bone; Bioinformatics; Gene; Pathology; Biology; Surgery; Genetics; Anatomy; Cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003209953,0.0005041862,0.001388222,0.0002172072,0.0006506022,0.00007632932,0.0002477943,0.0003692873,0.001867808],"category_scores_gemma":[0.0000198001,0.0003689804,0.0006109716,0.0002268063,0.0002296374,0.0000442968,0.00003390751,0.000528397,0.00001357593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001870362,"about_ca_system_score_gemma":0.0003676068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004890165,"about_ca_topic_score_gemma":0.00000130091,"domain_scores_codex":[0.9975744,0.0002419324,0.0007296542,0.0008012147,0.0002773461,0.0003753889],"domain_scores_gemma":[0.9982527,0.0001530207,0.000368894,0.0009358177,0.00007237972,0.0002172054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007512124,0.0004630256,0.0000528343,0.001610488,0.000625771,0.00001939077,0.0002933452,6.278776e-8,0.0002778349,0.0002065114,0.000683982,0.9956917],"study_design_scores_gemma":[0.002382285,0.0007835513,0.0004562606,0.0005342293,0.0002639704,0.0001689962,0.00003031403,0.0000017007,0.0001329666,0.0002210358,0.994661,0.0003636438],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005804144,0.9864495,0.00002185117,0.0001515995,0.0002155979,0.006549525,0.0002449967,0.0001746663,0.0003881672],"genre_scores_gemma":[0.0002541271,0.9914166,0.0004445438,0.0002025194,0.0003937637,0.003023995,0.001791366,0.000117599,0.002355542],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.995328,"threshold_uncertainty_score":0.9998762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2544577392098565,"score_gpt":0.425163469258499,"score_spread":0.1707057300486425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}