{"id":"W4225396535","doi":"10.3390/toxins14050319","title":"Probing the Mechanism of Action of Cry41Aa on HepG2 through the Establishment of a Resistant Subline","year":2022,"lang":"en","type":"article","venue":"Toxins","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Medical Research Council; Blood Cancer UK","keywords":"Mechanism of action; Biology; Mediator; Bacillus thuringiensis; Cell culture; Phosphorylation; Cell; Mechanism (biology); Cell biology; Microbiology; Bacteria; Biochemistry; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000281757,0.0003529584,0.0003047719,0.0002264406,0.0002122536,0.0003406928,0.0001830153,0.0002857178,0.001249113],"category_scores_gemma":[0.0002345794,0.0001256214,0.0002892008,0.0002270602,0.0002173553,0.0001799056,0.0002818182,0.0009607111,0.0006109535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003080363,"about_ca_system_score_gemma":0.0002237344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029702,"about_ca_topic_score_gemma":0.001232596,"domain_scores_codex":[0.9997823,0.00005355486,0.00002842328,0.00003448945,0.00005787178,0.00004338962],"domain_scores_gemma":[0.9997689,0.00005169448,0.00004977197,0.00005263279,0.00003582637,0.00004112632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003485697,0.00002641319,0.0001518357,0.000009850835,0.000002851202,0.00003029714,0.00002090185,0.00002027421,0.9992735,0.00003936995,0.00002161067,0.000368243],"study_design_scores_gemma":[0.00001492787,0.0006203593,0.004170502,0.000004379729,0.00001842913,0.0004786411,0.00008689237,0.0006563163,0.9910673,0.00002941279,0.002846488,0.000006347147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900931,0.000410901,0.005691473,0.0001504692,0.00003553663,0.000201681,0.001171795,0.000119846,0.002125381],"genre_scores_gemma":[0.9795053,0.0005396822,0.009126074,0.0001260412,0.00001166082,0.0002126219,0.002664378,0.0001214287,0.007692778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001249113,"threshold_uncertainty_score":0.004178643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059250348984196,"score_gpt":0.2639297329620012,"score_spread":0.2433372294721592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}