{"id":"W4225396535","doi":"10.3390/toxins14050319","title":"Probing the Mechanism of Action of Cry41Aa on HepG2 through the Establishment of a Resistant Subline","year":2022,"lang":"en","type":"article","venue":"Toxins","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Medical Research Council; Blood Cancer UK","keywords":"Mechanism of action; Biology; Mediator; Bacillus thuringiensis; Cell culture; Phosphorylation; Cell; Mechanism (biology); Cell biology; Microbiology; Bacteria; Biochemistry; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002609639,0.00007547883,0.0001076126,0.00001916624,0.0001150425,0.000003958879,0.0002362066,0.00003526784,0.00003423796],"category_scores_gemma":[0.00002634625,0.0000479738,0.00008043989,0.0001314372,0.00006827657,0.000001800626,0.0001164703,0.00008635512,2.30893e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001607779,"about_ca_system_score_gemma":0.00007566001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007955232,"about_ca_topic_score_gemma":0.0001345528,"domain_scores_codex":[0.9992211,0.00009127607,0.000220125,0.0001304472,0.0002245737,0.0001124726],"domain_scores_gemma":[0.9992998,0.0000193667,0.0001990962,0.0004047821,0.00006748536,0.000009515403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003213234,0.0001192069,0.00001283946,0.00003272049,0.00004063208,4.18895e-7,0.0005441307,0.0005398191,0.9900174,0.007353379,0.0007776255,0.000240539],"study_design_scores_gemma":[0.0002325072,0.0008585555,0.0001839299,0.0000105957,0.00002218858,0.000001940175,0.001390239,0.00002464247,0.9798341,0.0008950019,0.01649236,0.00005396165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964658,0.0003925026,0.0004188849,0.0004929642,0.0001085272,0.0002526442,0.0000634406,0.000002808917,0.001802418],"genre_scores_gemma":[0.998961,0.000138935,0.0001786014,0.0001604516,0.00004516243,0.00002839465,0.00002292689,0.000009601125,0.0004549803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01571473,"threshold_uncertainty_score":0.1956315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059250348984196,"score_gpt":0.2639297329620012,"score_spread":0.2433372294721592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}