{"id":"W4225399977","doi":"10.1096/fasebj.2022.36.s1.r4081","title":"Linoleic Acid‐Derived Diol 12,13‐DiHOME Modulates THP‐1 Macrophage NLRP3 Inflammasome Activation","year":2022,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Inflammasome; Inflammation; Macrophage polarization; Chemistry; AIM2; Arachidonic acid; Linoleic acid; Proinflammatory cytokine; Polyunsaturated fatty acid; Cell biology; Biochemistry; Fatty acid; Immunology; Biology; Macrophage; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001903879,0.0002930142,0.0003243629,0.0002455579,0.0001805293,0.0003464091,0.0001116536,0.000312348,0.001874146],"category_scores_gemma":[0.00009171141,0.0001676238,0.0002905767,0.0001705353,0.0002776442,0.0002728374,0.0002136982,0.0008178973,0.0004796002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001771558,"about_ca_system_score_gemma":0.0002069932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002346398,"about_ca_topic_score_gemma":0.0004707279,"domain_scores_codex":[0.9998307,0.00003947321,0.0000207055,0.00002945895,0.00002646588,0.00005312157],"domain_scores_gemma":[0.9999156,0.00001539298,0.00002158109,0.000009818306,0.00001305891,0.00002453536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008074524,0.00007307337,0.0002960652,0.00006760457,0.000005265077,0.00005318026,0.00002640605,0.00001940254,0.9976743,0.00002397141,0.00004683529,0.0009065791],"study_design_scores_gemma":[0.00008733237,0.000875935,0.01347189,0.00001953826,0.00002747763,0.0002006654,0.0001473718,0.0003946985,0.9831751,0.00007991921,0.001513621,0.000006570173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944773,0.001842984,0.001368049,0.0002168613,0.00006121066,0.00004605787,0.0005108276,0.00003590848,0.001440802],"genre_scores_gemma":[0.9934422,0.001560392,0.001982116,0.0002498344,0.00002428602,0.00009729634,0.0004413536,0.00001230569,0.002190215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001874146,"threshold_uncertainty_score":0.006269634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131131086622053,"score_gpt":0.2370663484942582,"score_spread":0.2239532398320529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}