{"id":"W4225402106","doi":"10.1096/fasebj.2022.36.s1.r2036","title":"<b>I</b> mpact of loss or regain of Equilibrative Nucleoside Transporter (ENT) Subtype‐1 on ENT Subtype‐2 pharmacology in a Novel CRISPR‐Cas9 HEK293‐ENT1KO Cell Model","year":2022,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CRISPR; Nucleoside; HEK 293 cells; Transporter; Nucleoside transporter; Chemistry; Pharmacology; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004110634,0.0004336751,0.000538172,0.0003254421,0.0002949023,0.0006366192,0.0005834614,0.0009297773,0.004437168],"category_scores_gemma":[0.0002641711,0.0002594334,0.0005790325,0.0002352403,0.0005053188,0.0004318338,0.0002744717,0.001574851,0.001572229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005033967,"about_ca_system_score_gemma":0.0004143821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002634366,"about_ca_topic_score_gemma":0.002954933,"domain_scores_codex":[0.9995461,0.00004316996,0.00006961604,0.0001135476,0.0001356642,0.00009183009],"domain_scores_gemma":[0.9997081,0.00005762462,0.00008299797,0.00004645688,0.00003698782,0.00006794672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003073709,0.0001037567,0.000290973,0.000112849,0.00001735219,0.0001452111,0.00003916072,0.0002391439,0.9949891,0.0004537201,0.001193919,0.00210747],"study_design_scores_gemma":[0.00005701438,0.0003635375,0.003530259,0.00001725082,0.00004983275,0.0006249075,0.00008546377,0.003752385,0.9809505,0.0001687675,0.01037485,0.00002509625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9233522,0.003179616,0.03253556,0.001950761,0.0008176605,0.0003352751,0.01334507,0.002589334,0.02189456],"genre_scores_gemma":[0.9557508,0.00172313,0.01954555,0.0006058969,0.00003234895,0.0005082172,0.004538218,0.0003327855,0.01696309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004437168,"threshold_uncertainty_score":0.01484382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01719710759251069,"score_gpt":0.3003252275401658,"score_spread":0.2831281199476551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}