{"id":"W4225409686","doi":"10.1016/j.jcyt.2022.03.005","title":"Rapid single-cell identification of Epstein–Barr virus-specific T-cell receptors for cellular therapy","year":2022,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Deutsche Krebshilfe; Consejo Nacional de Ciencia y Tecnología; Deutschen Konsortium für Translationale Krebsforschung; Charité – Universitätsmedizin Berlin; American Society of Hematology","keywords":"Biology; Epitope; Epstein–Barr virus; T-cell receptor; T cell; Adoptive cell transfer; CD8; Virology; Immunology; Human leukocyte antigen; Transplantation; Lytic cycle; Streptamer; Peripheral blood mononuclear cell; Virus; Antigen; Immune system; In vitro; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003631572,0.0004633715,0.0006299143,0.0003276574,0.0002351262,0.0008824163,0.0003841542,0.0007891332,0.002638595],"category_scores_gemma":[0.0004521139,0.0002308674,0.0002599824,0.0002376679,0.0002650819,0.0005145476,0.0003121105,0.001264536,0.001574906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003399343,"about_ca_system_score_gemma":0.000241162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002138721,"about_ca_topic_score_gemma":0.0006390394,"domain_scores_codex":[0.9998087,0.00003885637,0.000009633362,0.00004902836,0.00005622266,0.00003754889],"domain_scores_gemma":[0.9998109,0.00009267148,0.00001650582,0.00003288691,0.00002778607,0.00001931674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004184766,0.00001401126,0.00004966841,0.0000282715,0.000002807375,0.0000132321,0.00001702133,0.0000917448,0.996424,0.0003000477,0.0001503733,0.002866941],"study_design_scores_gemma":[0.00001402111,0.00009246308,0.0002289531,0.000004224491,0.000008549582,0.00008291484,0.00001944723,0.002858367,0.9937246,0.0001499828,0.002811863,0.000004684284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6339914,0.009531165,0.3384817,0.000693062,0.0005034138,0.001023995,0.001977949,0.001503875,0.01229338],"genre_scores_gemma":[0.8897939,0.00302826,0.09634177,0.0002656357,0.00005367419,0.0006296964,0.001076283,0.0001932545,0.008617627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002638595,"threshold_uncertainty_score":0.008827031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02795038362337784,"score_gpt":0.2491396886717555,"score_spread":0.2211893050483777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}