{"id":"W4225409686","doi":"10.1016/j.jcyt.2022.03.005","title":"Rapid single-cell identification of Epstein–Barr virus-specific T-cell receptors for cellular therapy","year":2022,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Deutsche Krebshilfe; Consejo Nacional de Ciencia y Tecnología; Deutschen Konsortium für Translationale Krebsforschung; Charité – Universitätsmedizin Berlin; American Society of Hematology","keywords":"Biology; Epitope; Epstein–Barr virus; T-cell receptor; T cell; Adoptive cell transfer; CD8; Virology; Immunology; Human leukocyte antigen; Transplantation; Lytic cycle; Streptamer; Peripheral blood mononuclear cell; Virus; Antigen; Immune system; In vitro; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004545472,0.0002132337,0.0003930913,0.0001755119,0.0002407923,0.00002326573,0.0002091724,0.00009971014,0.00224724],"category_scores_gemma":[0.000008582144,0.0002136825,0.0003078676,0.000399709,0.00007639366,0.00006750703,0.00001653292,0.0001834259,0.00001775178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002619285,"about_ca_system_score_gemma":0.0001190536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002693847,"about_ca_topic_score_gemma":0.000001812415,"domain_scores_codex":[0.9982377,0.000105661,0.0005237497,0.0004052273,0.0004084226,0.0003192377],"domain_scores_gemma":[0.9988613,0.00006603259,0.0003995155,0.0004622636,0.0001239924,0.00008691559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001366697,0.001055661,0.0003384892,0.0000460097,0.00006333107,0.000001738838,0.001306333,0.00005624174,0.9410685,0.00006711404,0.02700197,0.02762795],"study_design_scores_gemma":[0.006987868,0.001619317,0.00007334921,0.000007463376,0.00002205379,8.617262e-7,0.001051584,0.00006435417,0.5853415,0.000242151,0.4044082,0.0001812516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586325,0.0314997,0.002285836,0.000864931,0.001116233,0.001815875,0.0001363168,0.0001224156,0.003526238],"genre_scores_gemma":[0.986618,0.005949509,0.0003093291,0.0009504287,0.0001813424,0.0003160575,0.0002185755,0.0001099859,0.00534681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3774063,"threshold_uncertainty_score":0.9986649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02795038362337784,"score_gpt":0.2491396886717555,"score_spread":0.2211893050483777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}