{"id":"W4225419660","doi":"10.1038/s41388-022-02332-8","title":"RUVBL1 promotes enzalutamide resistance of prostate tumors through the PLXNA1-CRAF-MAPK pathway","year":2022,"lang":"en","type":"article","venue":"Oncogene","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"","keywords":"Enzalutamide; Cancer research; Biology; Prostate cancer; Cell growth; Downregulation and upregulation; MAPK/ERK pathway; Signal transduction; Cancer; Androgen receptor; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001078551,0.0003271156,0.0002225315,0.0002943369,0.0002417578,0.0005091429,0.0002874745,0.0002288492,0.002593953],"category_scores_gemma":[0.00009246785,0.0001901974,0.0003015659,0.0002010987,0.000223976,0.0002171101,0.0002334265,0.0009234762,0.0006274137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005922977,"about_ca_system_score_gemma":0.0004527343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001919917,"about_ca_topic_score_gemma":0.003997092,"domain_scores_codex":[0.9998357,0.0000234964,0.000008083579,0.00002783755,0.00003860688,0.00006616947],"domain_scores_gemma":[0.9999577,0.000003652251,0.00001158492,0.000005986758,0.000004256936,0.00001686051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003695206,0.0001586245,0.0008990332,0.00006807376,0.00002649929,0.00010833,0.0000196619,0.000337086,0.9923321,0.0004690923,0.0007368181,0.004475073],"study_design_scores_gemma":[0.0001316359,0.0005974482,0.02256472,0.00001572839,0.00007040268,0.0008154133,0.0001106618,0.004065599,0.9569516,0.0001925162,0.0144681,0.00001614846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990182,0.002926618,0.00156129,0.0004147342,0.0000597322,0.0000221966,0.000636027,0.0003541263,0.003843378],"genre_scores_gemma":[0.9946237,0.0006822066,0.0004466137,0.00005257914,0.000006054433,0.00001865142,0.0006728169,0.0000252004,0.003472266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002593953,"threshold_uncertainty_score":0.008677661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0282896923872465,"score_gpt":0.3023556937077532,"score_spread":0.2740660013205067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}