{"id":"W4225423622","doi":"10.1096/fasebj.2022.36.s1.r3187","title":"Characterization of CARM1 Inhibition in Skeletal Muscle","year":2022,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Methylation; Biology; Arginine; Skeletal muscle; Protein arginine methyltransferase 5; Protein methylation; Blot; Biochemistry; Internal medicine; Endocrinology; Methyltransferase; Molecular biology; Amino acid; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003158516,0.0004341804,0.0004980616,0.0002202153,0.0001716606,0.0002055595,0.000371852,0.0003049975,0.001609221],"category_scores_gemma":[0.0001252852,0.0001755205,0.0004037955,0.000211401,0.0001660052,0.0001399875,0.0001387208,0.0007557923,0.0005310681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003002297,"about_ca_system_score_gemma":0.000302535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001008585,"about_ca_topic_score_gemma":0.002120847,"domain_scores_codex":[0.9997976,0.00002069856,0.00001279248,0.0000535517,0.00006682087,0.00004849814],"domain_scores_gemma":[0.9998966,0.00001592295,0.0000215828,0.00001092976,0.00002635762,0.00002855352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001854655,0.00005424074,0.0001605812,0.0000556438,0.00001126725,0.00002187527,0.000009411803,0.00004126745,0.9972796,0.0000322638,0.00008276667,0.0020656],"study_design_scores_gemma":[0.00005430501,0.001788438,0.006043145,0.000008550464,0.00003287336,0.0001381159,0.00002187927,0.000705905,0.9871951,0.0000181595,0.003990137,0.000003548434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979989,0.007870746,0.006361754,0.0002702323,0.0001300314,0.0001665619,0.00169045,0.0002197131,0.00330158],"genre_scores_gemma":[0.9725759,0.003669918,0.005458192,0.0002993956,0.00003899341,0.0003935113,0.004355856,0.00009236596,0.01311587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001609221,"threshold_uncertainty_score":0.005383313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006610201749676038,"score_gpt":0.2158501860977026,"score_spread":0.2092399843480266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}