{"id":"W4225499852","doi":"10.1038/s41598-022-10121-2","title":"Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; St. Francis Xavier University; Simon Fraser University; BC Cancer Agency; University of British Columbia; Queen's University","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute of Environmental Health Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; Programme Grants for Applied Research; Instituto de Salud Carlos III; Cancer Council Victoria; Medical Research Council; Institut National Du Cancer; Centers for Disease Control and Prevention; Deutsche Gesetzliche Unfallversicherung; Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung, Wissenschaft und Forschung; Institut Gustave-Roussy; National Health and Medical Research Council; School of Public Health, Imperial College London; Deutsche Krebshilfe; Deutschen Konsortium für Translationale Krebsforschung; Fondation de France; Swedish Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Vetenskapsrådet; Mutuelle Générale de l'Education Nationale; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Canadian Institutes of Health Research; Cancerfonden; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Imperial College London; World Health Organization; U.S. Department of Defense; Cancer Research UK; Breast Cancer Research Foundation; McGill University; National Institute on Aging; Robert Bosch Stiftung; Government of Canada; Division of Cancer Prevention, National Cancer Institute; National Institute for Health and Care Research; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Lon V. Smith Foundation; Eberhard Karls Universität Tübingen; Fondation du cancer du sein du Québec; Génome Québec; National Institutes of Health; David F. and Margaret T. Grohne Family Foundation; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; European Commission; U.S. Department of Health and Human Services; World Cancer Research Fund; Susan G. Komen for the Cure; Agency for Science, Technology and Research","keywords":"Breast cancer; Hormone therapy; Medicine; Gynecology; Oncology; Hormone; Cancer; Bioinformatics; Obstetrics; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001444547,0.0003689614,0.0006985661,0.0009719487,0.0005468701,0.0006795368,0.0004672853,0.0005050578,0.002131141],"category_scores_gemma":[0.003262589,0.0003865153,0.001751871,0.001822344,0.0003058127,0.0002405665,0.0005212282,0.0005091635,0.0001302954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000305108,"about_ca_system_score_gemma":0.0003755707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01110624,"about_ca_topic_score_gemma":0.01369757,"domain_scores_codex":[0.9986278,0.0004829835,0.0001241607,0.000473978,0.0001415071,0.0001495175],"domain_scores_gemma":[0.9980249,0.001035004,0.0004092186,0.0002532823,0.0001092205,0.0001683172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001213318,0.00002835233,0.9914415,0.00005408034,0.003226067,0.0001675306,0.00008682054,0.0001419094,0.001845905,0.00005291087,0.0001894594,0.001552053],"study_design_scores_gemma":[0.0000591807,0.0001562328,0.9967986,0.00000979801,0.00153336,0.0001695505,0.00009219362,0.0005433604,0.0001962187,0.0000785644,0.0003556395,0.000007284687],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963602,0.00137051,0.0005204943,0.00009443599,0.00001899354,0.00001128957,0.001389892,0.00001708257,0.0002169487],"genre_scores_gemma":[0.998812,0.0001484177,0.0002379225,0.00002617945,0.00001163154,0.00001532587,0.0005983984,0.000005715656,0.0001443885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01110624,"threshold_uncertainty_score":0.02208322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087634937673648,"score_gpt":0.2537679009444531,"score_spread":0.2428915515677166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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