{"id":"W4225501232","doi":"10.1038/s41467-022-28324-6","title":"Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; University of British Columbia","funders":"Victoria General Hospital Foundation; Canada Excellence Research Chairs, Government of Canada; Canadian Institutes of Health Research; Genome British Columbia","keywords":"Kappa; Immune escape; Biology; Antibody; Haplotype; Neutralization; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Neutralizing antibody; Protein structure; Mutation; Genetics; Virology; Coronavirus disease 2019 (COVID-19); Computational biology; Immune system; Gene; Medicine; Genotype; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001125168,0.0001643339,0.00009712402,0.0000827007,0.000196204,0.0003544448,0.0002211835,0.0003062127,0.000917455],"category_scores_gemma":[0.0001754808,0.0001052538,0.0001738403,0.00009325392,0.0002877059,0.0002788531,0.0002834534,0.0004189736,0.0001805723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552979,"about_ca_system_score_gemma":0.0001378375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00116894,"about_ca_topic_score_gemma":0.001480137,"domain_scores_codex":[0.9999331,0.000009755811,0.000005322516,0.00001364951,0.0000192101,0.00001891922],"domain_scores_gemma":[0.99992,0.000009535993,0.00002270792,0.000009486342,0.000014296,0.00002384143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001388564,0.00001791838,0.008412547,0.00002764424,0.00001150409,0.0004117599,0.00007735278,0.0003497301,0.9892762,0.0005634765,0.00004942709,0.0006634958],"study_design_scores_gemma":[0.00004637858,0.0004703637,0.2166756,0.00002046361,0.00004806961,0.006179155,0.001260974,0.01019582,0.7606448,0.001275967,0.003157022,0.00002549187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985787,0.0001132544,0.0005325195,0.00005807008,0.000003575068,0.000003610706,0.00006627082,0.000006951851,0.0006371301],"genre_scores_gemma":[0.999348,0.00003907017,0.0002950374,0.00002810785,0.000001356742,0.000001722645,0.00007161427,0.000003367171,0.0002117418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00116894,"threshold_uncertainty_score":0.003069222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05301154152796093,"score_gpt":0.3817347220042378,"score_spread":0.3287231804762769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}