{"id":"W4225546854","doi":"10.21203/rs.3.rs-1063168/v1","title":"Complete Response of a Colonic High-Grade Neuroendocrine Carcinoma to Platinum-Based Therapy: Insights from Comprehensive Genomic Profiling","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority","funders":"","keywords":"Neuroendocrine carcinoma; Profiling (computer programming); Computational biology; Oncology; Internal medicine; Medicine; Cancer research; Carcinoma; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190777,0.0001942302,0.0002182908,0.0003868277,0.0001223103,0.000268681,0.0001524427,0.0004230513,0.0004480259],"category_scores_gemma":[0.0004763937,0.00009299151,0.0001420024,0.0002212313,0.0002116657,0.0001840638,0.0001880004,0.0003238549,0.0001430511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002659507,"about_ca_system_score_gemma":0.0001413169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008412375,"about_ca_topic_score_gemma":0.001159182,"domain_scores_codex":[0.9999079,0.00001548351,0.000008791005,0.00002589405,0.00002057327,0.00002131943],"domain_scores_gemma":[0.9997651,0.00009840697,0.00004517791,0.00002228209,0.00002173311,0.00004730561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0007948949,0.00005878347,0.2132259,0.0002025007,0.00006828958,0.4846265,0.0003555907,0.001516885,0.2361925,0.0006340459,0.001188707,0.06113551],"study_design_scores_gemma":[0.00002506549,0.0004566592,0.333724,0.00003395776,0.0001025051,0.6049066,0.0003186997,0.003568067,0.05019291,0.0007750202,0.005866188,0.00003031805],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882681,0.003267539,0.004260532,0.0007208525,0.00001971718,0.00003117645,0.0004108432,0.0001084338,0.002912881],"genre_scores_gemma":[0.9979641,0.0005185431,0.001028745,0.00008443817,0.00001720824,0.000004813233,0.0001400063,0.000007312127,0.0002348276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008412375,"threshold_uncertainty_score":0.001929641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1007285148640596,"score_gpt":0.3931116288731064,"score_spread":0.2923831140090469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}