{"id":"W4225550769","doi":"10.1093/brain/awac158","title":"Biomarker A+T−: is this Alzheimer’s disease or not? A combined CSF and pathology study","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Bijzonder Onderzoeksfonds UGent; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Stichting Dioraphte; Instituut Born-Bunge; IXICO; H. Lundbeck A/S; Meso Scale Diagnostics; Bentham-Moxon Trust; Servier; BioClinica; Biogen; Pfizer; Alzheimer Nederland; ZonMw; Amsterdam Neuroscience; Alzheimer's Association; Universiteit Antwerpen; Eisai; Amsterdam University Medical Centers; Northern California Institute for Research and Education; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Autopsy; Alzheimer's disease; Pathology; Medicine; Dementia; Biomarker; Cause of death; Cohort; Concordance; Disease; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003198139,0.0007901919,0.001066762,0.002186076,0.0007382582,0.002256041,0.0007681374,0.001045285,0.001507996],"category_scores_gemma":[0.007224917,0.0004071861,0.0007413151,0.001810924,0.0006661047,0.001703487,0.0009199015,0.0006027851,0.0008130749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003947714,"about_ca_system_score_gemma":0.0005887788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002077727,"about_ca_topic_score_gemma":0.00156043,"domain_scores_codex":[0.9988559,0.0002529151,0.0002227139,0.0003540233,0.0001939543,0.0001204834],"domain_scores_gemma":[0.9965349,0.0006484597,0.001184998,0.0003881217,0.0007556748,0.0004878334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002637342,0.0002220242,0.9688694,0.0001947878,0.0005973623,0.001233975,0.0004047882,0.00009402735,0.004776871,0.0002880969,0.0007138228,0.01996757],"study_design_scores_gemma":[0.000209614,0.002704102,0.9698977,0.000301708,0.001365215,0.01154772,0.001129519,0.0009372639,0.001792397,0.001957766,0.008087456,0.00006956724],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921042,0.004708552,0.0006703453,0.0002411186,0.00009781518,0.00004473,0.0003994479,0.00001227648,0.001721657],"genre_scores_gemma":[0.9971112,0.001126827,0.0005045548,0.0002125947,0.000172924,0.00002506152,0.0005645924,0.000006937466,0.0002751164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003198139,"threshold_uncertainty_score":0.01691353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0583447992201129,"score_gpt":0.3639108350563431,"score_spread":0.3055660358362303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}