{"id":"W4225550769","doi":"10.1093/brain/awac158","title":"Biomarker A+T−: is this Alzheimer’s disease or not? A combined CSF and pathology study","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Bijzonder Onderzoeksfonds UGent; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Stichting Dioraphte; Instituut Born-Bunge; IXICO; H. Lundbeck A/S; Meso Scale Diagnostics; Bentham-Moxon Trust; Servier; BioClinica; Biogen; Pfizer; Alzheimer Nederland; ZonMw; Amsterdam Neuroscience; Alzheimer's Association; Universiteit Antwerpen; Eisai; Amsterdam University Medical Centers; Northern California Institute for Research and Education; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Autopsy; Alzheimer's disease; Pathology; Medicine; Dementia; Biomarker; Cause of death; Cohort; Concordance; Disease; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000596582,0.0001147441,0.0001913669,0.0001477269,0.0002126152,0.00002277796,0.00008460693,0.00001830041,0.009947428],"category_scores_gemma":[0.0001867384,0.00009056763,0.00005033946,0.0002366356,0.00008622849,0.00004138977,0.0003357066,0.0001611482,0.00005977641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002367901,"about_ca_system_score_gemma":0.0001389277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003062636,"about_ca_topic_score_gemma":0.00000534946,"domain_scores_codex":[0.9984853,0.0003149342,0.0001585409,0.0003382809,0.0004305254,0.0002724593],"domain_scores_gemma":[0.9993039,0.0001423833,0.00003256484,0.0002360639,0.0000539777,0.0002311102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01770791,0.005608319,0.739445,0.00006678303,0.0007372342,0.00945098,0.003164419,5.753476e-8,0.003579671,0.0001215333,0.1512311,0.068887],"study_design_scores_gemma":[0.006664529,0.003274402,0.9614909,0.000008161936,0.000278072,0.00007712008,0.001592704,0.000176472,0.0001100922,0.00006251573,0.02613728,0.0001277789],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802238,0.0002745854,0.000008063441,0.01593884,0.00007244965,0.001288802,0.00006153459,0.00004563897,0.002086308],"genre_scores_gemma":[0.9762257,0.00001050835,0.00002355281,0.01003029,0.00002484386,0.0003449225,0.00003715285,0.00001846165,0.01328454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2220458,"threshold_uncertainty_score":0.9909576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0583447992201129,"score_gpt":0.3639108350563431,"score_spread":0.3055660358362303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}