{"id":"W4225605120","doi":"10.3389/fmicb.2022.833655","title":"Genetic Screening of Candida albicans Inactivation Mutants Identifies New Genes Involved in Macrophage-Fungal Cell Interactions","year":2022,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Concordia University","keywords":"Candida albicans; Mutant; Gene; Biology; Macrophage; Microbiology; Genetic screen; Cell; Fungal protein; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001286487,0.0008076825,0.0003933335,0.0004118925,0.0001243173,0.0002957926,0.0003543065,0.0003321755,0.0006869353],"category_scores_gemma":[0.0001740393,0.0001905363,0.0004937704,0.000384676,0.0001837173,0.0001274455,0.0002936907,0.0004585017,0.0003489888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002504894,"about_ca_system_score_gemma":0.0002343681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009299696,"about_ca_topic_score_gemma":0.001158763,"domain_scores_codex":[0.9998349,0.00001518645,0.00002322676,0.0000316252,0.00006455658,0.0000303884],"domain_scores_gemma":[0.9998066,0.00005074635,0.00006971943,0.00002377499,0.00001971591,0.00002947299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000552349,0.00002086436,0.0002702601,0.00001452971,0.000003828282,0.00005351039,0.000006281097,0.00004822579,0.9989502,0.00001960278,0.00001115279,0.0005463117],"study_design_scores_gemma":[0.000007802232,0.0001514473,0.009172793,0.000004983162,0.00002683492,0.000369761,0.00002758071,0.0007350105,0.9886289,0.00001603032,0.0008508767,0.000007945138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949497,0.000437582,0.003045173,0.00003290013,0.000008270787,0.00004501742,0.001017414,0.0001065351,0.0003574763],"genre_scores_gemma":[0.9883145,0.0005606919,0.006450276,0.00003659802,0.000004673114,0.00007577235,0.00255141,0.00007970829,0.001926358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009299696,"threshold_uncertainty_score":0.002298057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131563611466175,"score_gpt":0.2523347549169017,"score_spread":0.2391783937702842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}