{"id":"W4225620001","doi":"10.1021/acsmacrolett.2c00046","title":"Glycopolymer–Cell-Penetrating Peptide (CPP) Conjugates for Efficient Epidermal Growth Factor Receptor (EGFR) Silencing","year":2022,"lang":"en","type":"article","venue":"ACS Macro Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council","keywords":"Glycopolymer; Small interfering RNA; Internalization; Epidermal growth factor receptor; Raft; Chemistry; Peptide; Epidermal growth factor; Biophysics; Cell-penetrating peptide; Conjugate; Molecular biology; Biochemistry; Receptor; Polymerization; Biology; RNA; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001401182,0.0003036981,0.0001652601,0.0001500991,0.0000914156,0.0001646974,0.0001665756,0.000260412,0.0006854489],"category_scores_gemma":[0.0001287915,0.0001465042,0.0001660755,0.0001528867,0.0001319266,0.0002842335,0.0002035651,0.0004128404,0.0002671818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002384974,"about_ca_system_score_gemma":0.0001542997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002576529,"about_ca_topic_score_gemma":0.0003170481,"domain_scores_codex":[0.9999056,0.00001615954,0.000008603868,0.00002213428,0.00002984826,0.00001775338],"domain_scores_gemma":[0.9999515,0.000007557806,0.00001721018,0.000004734803,0.000008274213,0.00001078071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001961299,0.000007776023,0.00001957496,0.00002335205,0.000002718823,0.00002720767,0.00000757154,0.00009319172,0.9985409,0.00008131436,0.00002335666,0.001153436],"study_design_scores_gemma":[0.000007475076,0.000119641,0.000320776,0.000001589158,0.000006707865,0.0001108157,0.000002597379,0.0009410448,0.9971011,0.00001516936,0.001370005,0.00000310888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779251,0.002311662,0.01734753,0.0001123333,0.00003226189,0.000100875,0.000147092,0.0001634151,0.001859771],"genre_scores_gemma":[0.9865139,0.0009548984,0.01051099,0.00004664647,0.000009092259,0.00004763286,0.0001222356,0.00002387625,0.00177085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006854489,"threshold_uncertainty_score":0.00229305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049435853006583,"score_gpt":0.2309554101488024,"score_spread":0.2204610516187366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}