{"id":"W4225647476","doi":"10.1016/j.celrep.2022.110812","title":"LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":464,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada; AbCellera (Canada)","funders":"Defense Sciences Office, DARPA; Horizon 2020; National Institute of Allergy and Infectious Diseases; Office of Science; Defense Advanced Research Projects Agency; National Institutes of Health; Horizon 2020 Framework Programme; Vaccine Research Center; Eli Lilly and Company; Argonne National Laboratory; U.S. Department of Defense; U.S. Department of Energy; University of Texas Medical Branch","keywords":"Neutralization; Epitope; Monoclonal antibody; Virology; Antibody; Glycoprotein; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus; Biology; Molecular biology; Chemistry; Coronavirus disease 2019 (COVID-19); Immunology; Medicine; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001822349,0.0004587782,0.0003442539,0.0003110509,0.0001522548,0.0002751497,0.0003082895,0.0003172598,0.00131616],"category_scores_gemma":[0.0001309125,0.0001605735,0.0002253564,0.0001957523,0.0001548141,0.0001593837,0.0002019023,0.0006405626,0.0006232178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003478689,"about_ca_system_score_gemma":0.000343722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101784,"about_ca_topic_score_gemma":0.001043607,"domain_scores_codex":[0.9998257,0.00003298464,0.00001043484,0.00002331021,0.00006102998,0.00004651474],"domain_scores_gemma":[0.9999521,0.00000954863,0.000009721502,0.000004727834,0.000006897707,0.00001698038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002370872,0.0002369066,0.000347941,0.00002951066,0.00001476171,0.00002969359,0.00001498318,0.0003052382,0.9924133,0.00006224742,0.0001895155,0.006118756],"study_design_scores_gemma":[0.0004006964,0.007385094,0.007860275,0.000008713072,0.00004276859,0.0007326774,0.00001938051,0.00255394,0.9728785,0.00007817565,0.008029183,0.00001055548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937116,0.001398187,0.002045616,0.0001206857,0.00001958696,0.0001036269,0.0004293972,0.0001079332,0.002063501],"genre_scores_gemma":[0.9895622,0.001067709,0.003468167,0.0001226182,0.00001759875,0.00007677301,0.00251163,0.00002643047,0.003146997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00131616,"threshold_uncertainty_score":0.004402995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04240630903317812,"score_gpt":0.3260389030107508,"score_spread":0.2836325939775727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}