{"id":"W4225647604","doi":"10.1093/brain/awac124","title":"Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Occupational Cancer Research Centre; University of Toronto; University Health Network","funders":"Ministero della Salute","keywords":"Dementia with Lewy bodies; Pathology; Biomarker; Atrophy; Parkinsonism; Cytoplasmic inclusion; Tauopathy; Parkinson's disease; Medicine; Biology; Cytoplasm; Dementia; Disease; Neurodegeneration; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002771444,0.0001846855,0.0003048524,0.0001894125,0.0001380982,0.00001677224,0.0001272036,0.00006998075,0.0004993086],"category_scores_gemma":[0.00007990327,0.0001782781,0.0001832929,0.0003554453,0.0000130291,0.00003887431,0.00009498545,0.0001190817,0.00007680545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003575947,"about_ca_system_score_gemma":0.0002783297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006763692,"about_ca_topic_score_gemma":0.00005937738,"domain_scores_codex":[0.9985446,0.00008295462,0.0002663361,0.0004056593,0.0003545645,0.0003458587],"domain_scores_gemma":[0.9992264,0.0001016535,0.00007806211,0.0002940731,0.00002571857,0.0002740909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02992653,0.01142319,0.06527725,0.00266897,0.003668568,0.01684854,0.004141439,0.0008183725,0.2509818,0.009915298,0.3217094,0.2826206],"study_design_scores_gemma":[0.05209047,0.001754291,0.0548076,0.0004572563,0.0003565873,0.0002029576,0.002028464,0.06492215,0.02783113,0.0003442792,0.7942999,0.0009048923],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944191,0.0009901116,0.0004326593,0.001070316,0.0003785054,0.001561322,0.0002416895,0.0001586449,0.0007476592],"genre_scores_gemma":[0.9947675,0.00000398124,0.001410025,0.0005780825,0.00005595284,0.0003574001,0.000132044,0.00005529473,0.002639734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4725905,"threshold_uncertainty_score":0.7269971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01951975375097221,"score_gpt":0.250934947946174,"score_spread":0.2314151941952018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}