{"id":"W4225679609","doi":"10.1016/j.stemcr.2022.03.004","title":"GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation","year":2022,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; Heart and Stroke Foundation; The Scarborough Hospital; University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Biology; In vivo; Induced pluripotent stem cell; Progenitor cell; Transdifferentiation; Cell biology; Cellular differentiation; In vitro; Stem cell; Transcriptome; Embryonic stem cell; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006424193,0.0001276976,0.0002776212,0.0001623029,0.0001425813,0.00001374332,0.00003264279,0.0000346498,0.0002215227],"category_scores_gemma":[0.00004014141,0.00009232657,0.00007032548,0.0003290078,0.00003419559,0.00007035289,0.00006985632,0.0001547681,0.000004901678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009523629,"about_ca_system_score_gemma":0.00008547786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006934373,"about_ca_topic_score_gemma":0.000004100303,"domain_scores_codex":[0.9985603,0.0001381896,0.0005088603,0.0002286358,0.0003899749,0.0001740446],"domain_scores_gemma":[0.9990364,0.0001543074,0.0003351946,0.0002922253,0.00008099312,0.0001008925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009464197,0.0006768188,0.647773,0.0007263096,0.0002275251,0.0005200715,0.007961208,0.0014148,0.3216203,0.00005553442,0.01295919,0.005118847],"study_design_scores_gemma":[0.003078826,0.001662755,0.2606526,0.0001442605,0.001008063,0.0008708708,0.01337013,0.003780225,0.6901197,0.000301513,0.02453225,0.0004788422],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943608,0.0004179121,0.00006141546,0.0001279975,0.0003186034,0.0008380935,0.00001733584,0.00002683943,0.003831006],"genre_scores_gemma":[0.9969441,0.00002523656,0.00009253245,0.0001000152,0.0000421698,0.0001942278,0.00001331561,0.00001357278,0.002574778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3871204,"threshold_uncertainty_score":0.3764968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009029985696960544,"score_gpt":0.2090418899625461,"score_spread":0.2000119042655855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}